Toronto’s Medical Device Sector Climbs Global Rankings

By Sarah Mortimer, MaRS Discovery District

With venture capital and private equity investing hitting levels not seen since the dot-com boom, Canada is increasingly drawing foreign investors scoping the latest innovations. One of their areas of focus is the country’s medical device and equipment sector, which is now ranked ninth globally, according to Canada’s federal department of Foreign Affairs, Trade and Development.

“The medical devices sector in Canada is one to watch,” says Dan Mathers, investment director at the MaRS Investment Accelerator Fund (IAF), noting that the same government report estimates the sector’s worth at $6.8 billion, with additional exports totaling $1.9 billion. “Canada has always had a very strong ecosystem for driving innovation in health sciences, particularly in medical imaging, equipment and devices. The vision here is big.”

Over the past decade, Canada’s medical device sector has seen steady growth, with close to 1,500 medical device firms based in the country (not including medical imaging or assistive device companies), and a growing number of companies being acquired internationally. For example, companies like Mitra (acquired by Agfa), Karos Health (acquired by Vital Images) and Sentinelle Medical (acquired by Hologic) have paved the way for a new generation of companies getting noticed on the global stage.

Many of these firms are based in Toronto, the fourth-largest city in North America, as well as Canada’s largest city and a hub for innovation and entrepreneurship. “There’s a lot of activity here,” said Mathers, referring to successful medical device companies like Perimeter Medical Imaging, Synaptive Medical, eSight and Intellijoint Surgical. “With all the research centres and innovation activity in Toronto, you end up with the ability to turn what was previously science fiction into real-life solutions.”

This growing reputation is drawing investors to Toronto’s annual Redefining Early Stage Investments (RESI) on MaRS conference on April 4. Canada’s largest health investor event, it connects investors to the country’s top health startups across a range of key sectors, including medical devices. Over 150 investors have already confirmed attendance. This year, RESI on MaRS will be followed by MaRS HealthKick on April 5, an invite-only event that will see a select number of companies pitch to investors for the opportunity to win a cash prize.

Mathers, who has invested in eSight and Intellijoint Surgical – both of which recently expanded to the US market – believes Toronto’s concentration of top talent and “hospitals and universities with significant research budgets” is part of what makes the city an ideal location for medical device ventures. For example, the University of Toronto, which ranks 11th worldwide for clinical research and first in Canada for innovation, is located within a short walk of five renowned research hospitals and just across the street from MaRS Discovery District, an innovation hub that is home to a range of tenants, including life science giants like Johnson & Johnson’s JLABS incubator.

All of this is reflected in the bold medical device research currently taking place in the city. “Investing money in trialing new technologies is one of our greatest strengths,” said Mathers, adding that the US National Institutes of Health has ranked Canada third globally when it comes to the number of sites for active clinical trials for medical devices.

Generous funding opportunities for medical device businesses are another draw for investors, Mathers says. A number of Toronto-based venture firms, including MaRS IAF, the Business Development Bank of Canada (BDC), Genesys Capital and Lumira Capital, include the medical devices sector as a specific area of focus. The country also offers “significant grant money” for medical device businesses, Mathers says. For example, it offers up to $500,000 in low-interest loans for small businesses, as well as federal research grants, federal tax credits like SR&ED and market readiness funding from organizations like the Ontario Centres of Excellence.

These factors, combined with the low cost of manufacturing medical devices in Canada and the expertise and entrepreneurial support of organizations like MaRS, all lead Mathers to predict “accelerated growth for the sector.”

Arun Menawat, CEO of Profound Medical – a company that makes a real-time MRI-guided ultrasound procedure that destroys cancer cells in the prostate while sparing surrounding tissue – says it’s an exciting time to be in the medical device industry in Toronto.

“There has been a stream of medical device companies that have successfully created growth in the area,” he said. “I think that trend is likely to continue.”

Profound Medical won the MaRS HealthKick Challenge in 2014 and is among the many Canadian medical device companies heading to this year’s RESI on MaRS conference. The company, which went public two years ago, has since grown to a market valuation of $50 million. And in a sign of continued momentum, they secured $17.4 million in bought deal financing just last October.

“There are more and more people in New York and San Francisco who are getting the message that there is a pool of talent in Toronto, which is a great thing,” Menawat says, adding that he looks forward to connecting with investors and other great minds in the medical device industry as Profound prepares to present at this year’s conference.

“Getting the medical device community together is something I’m always excited about,” he says. “I think there’s going to be a lot of talent at that conference.”

 

Healthcare IT Investors Share Their Strategies at RESI on MaRS

By Cole Bunn, Senior Research Analyst, LSN

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Healthcare IT entrepreneurs, as opposed to biotech/medtech entrepreneurs, enjoy some favorable realities when it comes to successfully launching and sustaining a new venture. However, even though software and healthcare IT companies require far less capital than a biopharmaceutical product or medical device to get up and running, investors tend to place an emphasis on market penetration and traction, often the rate limiting step for these startups. A key to overcoming this hurdle is healthy ecosystem with innovative institutions willing to put programs in place to help new digital health technologies enter the marketplace and refine their product.

Canada is embracing digital health and the impact it can have on the public, patients and the healthcare system at large. Toronto, as the epicenter of Canadian healthcare and innovation, is naturally working to catalyze venture creation in healthcare IT and will host the RESI conference and a panel of venture investors active in the space.

The session will feature the following investors:

By registering for RESI on MaRS, you’ll be able to listen to the Healthcare IT panel live, interact with the investors and experience numerous opportunities to expand your network.

Hot Investor Mandate 1: Cross-Border Fund Invests in Highly Innovative Early Stage Medtech, Diagnostics and Healthcare IT

A VC firm with offices in California, Beijing, and Hong Kong manages over 100 portfolio companies in the US and China. The firm generally invests in the early stages, mostly in seed and Series A rounds. The firm focuses its investments in U.S. and China, but also considers companies based in Canada.

In the life sciences sector, the firm will consider medical technology, diagnostic, and healthcare IT companies. The firm is open to all types of medical technology in all types of indications, and will look at both 510k and PMA medical devices in development or clinical trials. Previously, the firm has also invested in the synthetic engineering space.

The firm is looking for early-stage companies with a highly innovative product. The management team of potential portfolio companies is expected to be committed to the company full-time and will have a track of strong, successful entrepreneurship. The firm does not require a board seat in its portfolio companies.

If you are interested in more information about this investor and other investors tracked by LSN, please email mandates@lifesciencenation.com

Hot Investor Mandate 2: Seed Investment Firm Raises New Fund, Seeks Healthcare IT Opportunities

An early-stage seed fund based in Palo Alto, CA focuses on seed stage and sometimes Series A. Typical equity allocations range from $500 – 750 K per company. The firm is open to both leading and co-investing. The firm has been investing from a $50M fund and is currently raising a new fund, from which it expects to make new investments. The firm is seeking opportunities from across the US with a focus on the Bay Area.

The firm invests across multiple industries including healthcare IT. The firm prefers products that do not require FDA approval. Within healthcare IT, the firm considers both consumer-facing and enterprise solutions that demonstrate customer traction and large market potential.

The firm can work with incomplete management teams and would require a board seat on a case-by-case basis. The firm has funded companies in which the founders were either current students or recent graduates from top US universities

If you are interested in more information about this investor and other investors tracked by LSN, please email mandates@lifesciencenation.com

Hot Investor Mandate 3: China-based Firm Invests in Preclinical Drugs in Oncology and Chronic Diseases

The biotech and healthcare subsidiary company of a large real estate corporation in China is interested in biotech technology, products and services with large potential in the Chinese market. The firm aims to launch them in China through partnership, investment and cooperation. Typical equity investments range from US$0.7-1.5 million (RMB 5-10 million), up to 3.5 million in later stage companies. The firm prefers to co-invest in a round with a strong, reputable lead. The firm considers opportunities from around the world with a focus on China, the US, and Australia.

The firm is interested in preclinical therapeutic projects in oncology, chronic diseases such as diabetes, and other disease indications with large market potential. The firm is open to all therapeutic modalities.

The firm is looking for experienced teams backed by strong lead investors. The firm may request board representation on a case-by-case basis.

If you are interested in more information about this investor and other investors tracked by LSN, please email mandates@lifesciencenation.com

Hot Investor Mandate 4: New Subsidiary of Investment Firm Seeks Technology-Driven Medical Devices

A Chinese investment company has founded a new U.S. based subsidiary, which typically makes seed investments of US$50k-250k in technology companies. The firm is currently focused on companies based in the Cambridge, MA area, but it is also open to opportunities from across the US. The firm would prefer companies with a China angle although they are open to investing in companies with a U.S. focus.

Within healthcare, the firm is currently interested in technology-driven medical devices, robotics, and artificial intelligence. The firm is not interested in software-only products.

The firm is looking for founders with strong academic credentials and sector expertise.

If you are interested in more information about this investor and other investors tracked by LSN, please email mandates@lifesciencenation.com

30 Leading Life Science Startups Compete in Innovation Challenge at The Redefining Early Stage Investments (RESI) Conference at MaRS

By Michael Quigley, VP of Market Research, LSN

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As RESI gears up for its second landing on MaRs in Toronto this April 4th we are proud to announce our latest batch of life science/health tech companies that will be participating in the RESI Innovation Challenge.

30 companies from across North America, hand selected by LSN’s scientific and commercial review team, will compete directly on merits of innovation and commercial viability.  Past RESI events have seen as many as 50% of innovation challenge contestants go on to receive funding or significant partnerships within a year from the competition.

From companies helping to detect oncoming seizures to those developing cost effective ways of growing blood stem cells, this diverse class of competitors is sure to impress. Come check them our yourself in the Exhibition Hall at RESI on MaRs on April 4th!

Therapeutic
 
Diagnostic
Medical Device
 
Healthcare IT