Drugs, Devices, Diagnostics and Digital Health Are Converging, And Investors Are Taking Notice

By Dennis Ford, Founder & CEO, Life Science Nation; Creator of RESI Conference Series

LSN has studied the breakdown of investor participants in Redefining Early Stage Investments (RESI) conferences over the course of the last year, and we found over 1000 North America-based investors, over 250 Asia-based investors and over 150 Europe-based investors, most of whom attended more than one RESI event. The fundraising CEOs who seek out these investors come to RESI in similar numbers, making the investor-to-entrepreneur ratio at all RESI conferences about one to one, unheard of for a partnering conference.  The RESI conference, due to its focus on early stage life science technologies, provides a present view of how the market is changing by bringing together the players on both side of the table – the early–stage buyers (investors and partners) and the early–stage sellers (scientist-entrepreneurs). As we all know, the healthcare arena and landscape is under dramatic change, with an enormous number new products and services that will become integrated into the healthcare industry.

When we look at these new products that entrepreneurs are showcasing at RESI, we see that they run the gamut from iterative (100 million + in market potential), to breakthrough (one billion +) to transformative (one trillion +).  The LSN Company Platform additionally collates information on tens of thousands of life science companies around the world.  As an example, we used the Company Platform to search for companies with products for surgery, and this is what we found:

Pre-Op

Surgery

Post-Op

Therapeutics/Diagnostics

1619

122

1542

Medical Device

1448

923

1452

Digital Health

326

25

335

This search was performed using the metrics the industry currently uses to define in which sector a company belongs. However, it is becoming extremely hard to classify these companies into discrete silos, as many of these technologies can be included in multiple categories. The industry will have to adapt as the boundaries between sectors become more and more tenuous. 

The lines are blurring all over the healthcare arena. Drugs will be inside intelligent devices connecting to networks of intelligent micro sensors outside and inside the body feeding data to the cloud apps and reporting and adjusting in and out of mobile devices, changing the way patients will cope with debilitating diseases.  Recent technological advancements are changing the face of medical care, including in the OR and pre- and post-op environments. The advent of digital health is leading to better patient monitoring systems, preventing potentially deadly outcomes while reducing the burden on hospital staff.  In addition, medical devices are becoming smaller and smarter, taking advantage of the ability to interface with devices outside the body to monitor improvements and alter treatment plans to increase efficacy.

While these advances are exciting, they do come with many challenges. The lines between therapeutics, diagnostics, devices and digital health are intersecting, and it is now common for products to touch multiple silos. This also increases the difficulties in gaining approval from regulatory agencies, as the evaluation is no longer so clear cut due to the overlap. However, regardless of the challenges, new technologies will come that improve patient outcomes, reduce complications and allow us to perform surgeries that were previously considered impossible.

Many of the investors who share their mandate information with LSN have expressed an interest in areas of convergence between the traditional technology silos in life sciences; investors express interest in digital therapeutics, tech-enabled medical devices and health services, and personalized medicine technologies that encompass elements of both diagnostic and therapeutic breakthroughs.

In RESI and the LSN data platforms, LSN essentially has a crystal ball looking into the future of healthcare!

Hot Investor Mandate: CVC Arm of Japanese Pharmaceutical Seeks Novel Therapeutics and Diagnostics Across Neuroscience, Immunology, Inflammation, Rare Disease & Platform Technoogies

A corporate venture subsidiary of a Japanese pharmaceutical is looking to provide equity capital to seed and venture stage companies in the life science space, and invests across North America & Europe. The firm is looking to provide companies with $5 million over the lifetime of the investment and plans on making 2-3 investments over the next year.

The firm is currently looking for novel therapeutics, platform technologies, diagnostics, and vaccines. The firm is interested in novel drugs in broad disease areas including neuroscience (particularly neurodegeneration), immunology, inflammation, and rare disease, as well as diagnostics for neurodegenerative disorders. Current platform technology areas of interest include regenerative medicine, synthetic biology, microbiome, gene therapy, and nucleic acid medicine.

The firm strongly prefers that the company has a strong management team with experience in the industry. The firm historically has only invested as a co-investor although they are capable and looking to take a lead position if the correct opportunity arises. The firm is looking to allocate to companies that will eventually be able to partner long term with its parent company.

If you are interested in more information about this investor and other investors tracked by LSN, please email mandates@lifesciencenation.com.

 

Hot Investor Mandate: USA & China Headquartered Cross-Border VC Invests in Therapeutics, Medical Devices, and Digital Health

A venture capital investment firm with offices in USA and China is investing from its US$200 million fund with a focus on high-tech enterprises in China and Western countries. The firm seeks to invest in innovative enterprises in sectors including: biomedicine, medical devices, healthcare and bio-tech. Typical equity investments range from $1-6 million in Angel, Series A and B rounds. The firm is looking for opportunities in China, the US and Canada.

Within healthcare, the firm considers biomedicine, medical devices, and digital health. The firm is most interested in personalized medicine products with an angle to the China market. Within digital health, the firm prefers home-care, consumer, or physician-patient interface products. The firm considers products from Angel Round to Series B.

The firm is looking for competent management teams. The firm may request distribution rights on a case-by-case basis.

If you are interested in more information about this investor and other investors tracked by LSN, please email mandates@lifesciencenation.com.

 

Hot Investor Mandate: Evergreen Fund Involved with Sovereign Wealth Invests All Across Life Sciences and Healthcare, with Interests in Novel Technologies Including Genomics and Stem Cells

A Life Science focused private equity and venture capital firm involved with a sovereign wealth fund is actively making investments. The firm generally makes longer term investments than a typical VC. The firm does not make seed investments, but is interested in both early stage venture capital investments and late stage companies seeking growth and expansion capital. Typically, the firm invests USD 5-15 million per opportunity. The firm can invest globally and is actively seeking new investment opportunities.

The firm seeks to invest in breakthrough healthcare biotech, medical devices, diagnostics, digital health, and biorenewable and bioindustrial technologies. The firm is open to a wide range of technologies including novel techniques such as stem cells and genomics, and will consider investing in any area of medicine. The firm prefers to invest in technologies that have attained clinical validation.

The firm seeks a strong and experienced management team. The firm may take a board seat on a case by case basis.

If you are interested in more information about this investor and other investors tracked by LSN, please email mandates@lifesciencenation.com.

 

Hot Investor Mandate: USA-Based Venture Capital Firm Invests in Medical Devices, Diagnostics, and Digital Health with Strong Interest in Technology-Based Products

A venture capital firm based out of Eastern USA is focused on companies in the healthcare field with a preference for innovative technology-based companies in Medtech, Diagnostics, and Digital Health. For medical devices, The firm will invest in both PMA and 510k devices and prefers to see some clinical validation. The firm is currently looking for 2-3 investments to close out their second fund in the coming year, and is in the process of raising a third fund with a first close to take place in 2019. The firm is stage agnostic but most often first invests $1-3M in Series A-B and reserves funds for follow-on investments. Most of the firm’s investments have been in the US and Israel, but the firm is open to investing globally.

The firm invests in companies with medical device, diagnostics and digital health technologies, focusing on innovative companies that can revolutionize their space. The firm favors technology-based products, such as genomics-based diagnostics or high-tech medical devices. Within digital health, the firm is fairly open, but has an interest in companies developing tools for clinical trials and other products developed for payer networks or Big Pharma. The firm is also interested in digital health technologies for hard-to-reach patient populations, such as those suffering from mental health disorders or substance abuse. While fairly opportunistic with regards to indication, the firm is particularly interested in technologies in the COPD, pulmonary hypertension, orthopedic and neurological space as well as products using ablation to treat pain.

The firm wants to see a strong CEO and Board when making investments. While often a not a lead investor, the firm is very active and will frequently take a Board seat after investing. The firm is looking to lead more investments when investing from their third fund.

If you are interested in more information about this investor and other investors tracked by LSN, please email mandates@lifesciencenation.com.

 

Robot Wins Innovation Challenge! What’s Next?

Dwight Meglan
An interview with Dwight Meglan, Founder/CTO, HeartLander Surgical, Inc.

– By Greg Mannix, VP of International Business Development, LSN

Greg Mannix

Dwight has a fascinating background in robotics. In fact, there are probably not many people out there who can rival his experience applying robotics to medical applications, which he has been doing since the 1990’s in companies ranging in size from start-ups to Medtronic, where Dwight still collaborates. So it shouldn’t come as a surprise that Dwight has started a company, HeartLander, that was the talk of the Exhibit Hall at our past RESI conference because of it’s surprising technology. Imagine a tiny robot that can move along the surface of a beating heart—simulating the movement of an inchworm—to deliver therapy to places not accessible until now. That’s what HeartLander does, and Dwight got so much interest in his little robot that he was the winner of the Innovation Challenge.

Greg Mannix (GM): Congratulations Dwight on winning the IC. Did you make some good connections at the RESI conference?

Dwight Meglan (DM):  Yes, we did. I think we caught the eye of quite a few walk-bys because we had a prototype of the robot with us and were doing a demo. We met a lot of people right there at our poster. We also had some good partnering meetings.

GM: How did you juggle the partnering meetings and time at the poster? You seem to have done very well.

DM: Actually, we were very selective about who to meet with. We are very early stage. But the meetings we did schedule, we met the investors at the assigned table and said “Hey, would you like to come see our poster?”. And we ended up having our meetings right there.

GM: Did you get any traction with the investors you spoke to?

DM: Yes, I think we did. We are following up with several of them, and some others want to stay in touch and reconnect when we have more preclinical data. My focus was to try to get across two things to the investors: one, how this technology will help make the world a better place; and two, how this technology will make economic sense. If they understood those two points, I think we were successful.

GM: Why do you think you won the IC?

DM: I just asked everybody to invest their RESI cash in us. If you don’t ask, you don’t receive!

GM: Sound words of advice. Thanks, Dwight.

HeartLander Surgical, Inc.

The HeartLander System’s new approach to debilitating ventricular (heart) conditions comprises low cost disposables and an inexpensive, reusable controller: 1. Disposable sensor array placed on the outside of the torso 2. Disposable, tethered, percutaneously delivered, epicardial walker with multimodal sensing (e.g., Doppler ultrasound for avoiding coronaries) and insertable needle for saline-enhanced radiofrequency ablation (creates small, precise lesions) or for delivering therapy into the myocardium 3. Control System that integrates sensor data, maps the heart defect, actuates the walker, plans actions, and provides a visualization display screen and control interface for the physician. Our first clinical focus (NIH-funded through animal PoC) is ventricular tachycardia, but the technology platform can be used for myocardial regeneration therapies, ventricular reshaping, and biventricular pacing.

First Coast Innovation Challenge Brings Top Tech Assets to Global Investors at RESI Boston

By Bryanna Allison, Business Development Manager, LSN

RESI wrapped up its 19th conference this month in Boston, with a record turnout and plenty of great connections made to move the needle in the life sciences. For some time now, the investors and strategic partners who regularly attend RESI have asked us to help them gain exposure to the earliest stage technologies being developed. Our idea was to create a new addition to the traditional RESI content and call it the First Coast Innovator’s Gathering, an event to showcase technology hubs from the “First Coast” – DC to Boston – and the early-stage companies being developed within their programs.

The feedback we got was extremely positive as the data below attests to:

  • 21 Tech Hubs had a table at the Gathering
  • 75 entrepreneurs from these Hubs attended
  • 36 projects presented a poster in the First Coast Exhibit area
  • 25 companies applied to the Pitching Competition
  • 8 finalists pitched to a panel of 6 investors
  • All the finalists were offered the chance to follow up with the panelists

RESI has become the conference of reference for connecting key players in the early-stage life science space. The turnout and level of engagement of investors, strategic partners, fundraising CEOs and specialized service providers is completely unique, and the Innovator’s Gathering in Boston has added a new dimension to the conference.

All of the positive feedback has encouraged us to adopt this format at future RESI conferences, so we are busy getting the word out to tech hubs in the Greater New York area for our upcoming New York conference to be held in Midtown Manhattan on November 5th.