Crossing the Atlantic: European Startups Finding Funding at RESI

14 Sep

By Rikki Piccirillo, Marketing Manager, LSN

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In this episode, join host Dennis Ford, Founder & CEO, Life Science Nation; Creator of RESI Conference Series as he engages in a captivating conversation with Greg Mannix, a leading expert in the world of life sciences investment. Together, they discuss the exciting world of European startups making their way across the Atlantic to seek funding opportunities in North America, with a particular focus on the opportunities in the city of Boston.

Greg Mannix, a driving force behind the RESI Conference, shares his wealth of knowledge and experience in helping European entrepreneurs navigate the complex terrain of North American investment. As the Managing Director at Life Science Nation (LSN) and an advocate for international collaboration in the life sciences industry, Mannix offers insights into the strategies, challenges, and success stories of European startups entering the North American market.

Discover why Boston, often referred to as the “Silicon Valley of the East Coast,” is the prime destination for European life science companies seeking funding. Dive into the thriving ecosystem of biotech, medtech, and digital health innovations and find out how the RESI Conference connects these European innovators with the vast investment opportunities in the United States.

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Interview with Martin Gershon, Managing Partner and CIO at Endeavor Venture Fund & Venture Studio

14 Sep
Martin-GershonMartin Gershon Interview with Martin Gershon, Managing Partner and CIO at Endeavor Venture Fund & Venture Studio

By Love Chung, Investor Research Analyst, LSN

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Love Chung (LC): Thank you for meeting with me this morning, Martin. Before we get started on asking you some specific questions, could you give us a brief introduction of Endeavor Venture Fund and Venture Studio?

Martin Gershon (MG): Thank you very much for having me here today. I am Dr. Martin Gershon. I’m the managing partner and the Chief Investment Officer for Endeavor Life Sciences Venture Fund and the Venture Studio. The Venture Fund was formed in 2009 and we are in our third fund. Now, the second one being Endeavor II and the third being the Venture Studio. Endeavor II has $1B of assets under management and the Venture Studio has $570M. We focus primarily on digital health, which includes drug discovery, drug development, precision medicine, personalized medicine, telemedicine, but we also do a lot of biotech. In fact, Endeavor I was a biotech firm including investments in Moderna.

We also look at mental health, women’s health and most recently in gene therapies and rare diseases. Typically, our check sizes for Endeavor II are $5-25M. For the Venture Studio, $100,000 to $500,000, up to a total of $5M for Pre-seed to Series A companies.

LC: Thank you for that introduction. I want to ask, as this is your first time attending RESI, what are you looking most forward to?

MG: Well, I’m very excited about moderating the panel on AI in Healthcare. It is a tremendous opportunity to be really close at hand with leading CEOs and entrepreneurs who are driving incredible new discoveries in AI and machine learning and the digital healthcare space. I look forward to speaking with incredible and seasoned industry leaders, investors, and it’s going to be a very dynamic process and I’m also excited about being a judge in two sessions, oncology and therapeutics.

LC: It’s your first time, but you’re already so involved! What kinds of companies or startups are you hoping to connect with?

MG: Well, that’s just a fantastic question because right now it’s really a floodgate of incredible companies, entrepreneurship is alive and well, even though we have a liquidity crisis, so the types of companies that we’re really interested in meeting first and foremost are in the digital space, but really, it’s about leadership and it’s about the CEOs that really drive the connection between us as investors and the technology.

So very important to us is the CEO perspective, the mission and the vision of the CEO, the ability for the CEO to be a leader, adapt, pivot, and grow. The Venture Studio looks for CEOs who have those qualities because very important to us are companies within the digital space, within the biotech space, and the other areas of investment, that we partner really from the get-go to strategics to look for exit strategies.

So, for us, the company is a combination of technology and management and the ability to be a good communicator, a good partner, and a good collaborator with those people that we want to come early in the process to look for involvement with.

LC: Thank you so much for all the details. How do you intend to evaluate investment opportunities that you come across at the conference?

MG: Another great question. Investment opportunities are really for us a four-part diamond shape approach. The first is, we really want CEOs who know how to collaborate and partner, who know how to adapt pivot and grow, who are coachable and who understand that it is an iterative process between the technology, the company’s vision, the investors, and most importantly, the strategics who are going to come in and be acquirers.

The second part is we want companies that know that it’s very important to be between the high demand and high liquidity corridors. What that means for us is that we are very, very interested in understanding where the drivers are to be able to move that product to commercialize an event and eventually to an exit. High demand means that industry wants that product, consumers want that product, patients want that product. High liquidity means that there’s already investment in that sector and growing.

And so, we put all the pieces together to look for companies and bring those in an iterative fashion in our workshops in our symposiums and in our BetterHealth webinar. Each week, two strategics, two industry leaders to be able to showcase these companies and say, how can we do a better job? What is it that we can do for you to create a customized package that you are interested in investing in or acquiring? Those are the types of companies that really prick up our ears.

LC: Thank you. As we’ve been talking about how you intend to evaluate investment opportunities and what kind of companies that you’re looking for at RESI, can you share a successful investment story and what made it successful?

MG: Absolutely. So early on in the process, we look for companies that have outstanding potential, which means great management, great leadership, and great technology. One of those early companies was Moderna. We did not know that there was a pandemic coming like anybody else. But we knew that there were tremendous, tremendous technological innovation, leadership and people like Bob Langer who have years and years of experience creating startups.

I do a lot of work with MIT and Harvard. I’m a visiting teacher and lecturer there and coach many of the companies. For many years, I am on the inside of understanding what’s happening in the labs, what’s happening with great professors who are entrepreneurs. And Moderna is one of those clearly, clearly above everybody else, head and shoulders, a real leader, a real understander of what is necessary in terms of new, platform technology.

And so Moderna really is a story that we approached early on because of its ability to grow, its ability to use its technology in multiple platforms. I think that we are going to see more and more of the technology that is embedded in Moderna come out over the next decade and longer to make it one of the preeminent BioPharma companies in the world.

LC: Thank you! And I just wanted to ask you one last question. What advice would you give to startups or companies attending RESI who are seeking investments from someone with your expertise?

MG: Such a fantastic question. So, I write articles, I teach about leadership I teach about entrepreneurship and about the new wave of CEOs and C-suite executives that are necessary for early stage companies. As new leaders, you have to have certain skill sets that you didn’t have 10 years ago.

Now, in 2023, it’s especially important to understand that investors want a risk adjusted investment. What does that mean? It means that it’s very, very important to understand that even though you have incredible innovation, you have to present yourself to investors as they see themselves. So that means that every investment has a risk adjustment to it. You must mitigate that risk.

We mitigate that risk in Endeavor by creating opportunities to generate revenue. So, my advice to investors is find those CEOs that understand this process. And my advice to CEOs is understand the investor perspective, mitigate risk, be adaptable, be customizable, find different ways to use your product in a platform technology and most importantly generate revenue.

LC: Thank you for all the insightful responses.

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Hot Investor Mandate: CRO Turned Healthcare VC Invests $15-20M in Promising Therapeutics and Medtech Companies in Early Clinical Stage

14 Sep

A healthcare-focused investment firm had its beginnings as a CRO, helping companies execute clinical trials. This is still an important component of the firm’s unique business model, but in addition to this, the firm now seeks to actively invest in promising projects like a traditional venture capital fund. In addition to investing in companies, the firm seeks to leverage its capabilities to help companies with clinical trials in Central Asia. Executing clinical trials in Central Asia is much cheaper, allowing companies to validate their technologies on a faster, efficient basis. The firm is capable of investing $15-20M over the company’s lifecycle, and seeks companies globally.
Within life sciences, the firm seeks opportunities in therapeutics and medtech. Ideally, the firm seeks to engage in companies who are in early clinical stage – beyond Phase I – but is open to engaging with earlier projects. The firm is opportunistic in term of subsector and indication.

The firm seeks companies backed by innovative science and experienced management teams. As mentioned earlier, the firm is equipped to help companies execute clinical trials on a faster, more efficient basis, and has deep relationships with regional governments and leading institutions to make this possible.

If you are interested in more information about this investor and other investors tracked by LSN, please email mandates@lifesciencenation.com.

Hot Investor Mandate: USA & China-Based VC Invests Broadly in All Life Science Sectors, With Strong Interest in CVD, Oncology, and Women’s Health

14 Sep

A venture capital firm based in the US with additional offices in China has built three arms to support their portfolio companies, which is broken down to the following: (1) Investment: The firm invests in early-stage life science ventures, from Seed to Series B, with Series A and Series B being the firm’s sweet spot. Typical size of investment ranges from $1-2M in seed stage companies, and $3-5M in venture round companies. (2) Advisory Service to C-Suite: The firm supports entrepreneurs to expand to the Chinese market, and the firm has multiple offices in China and needed expertise to support the entrepreneur’s vision. (3) Analytics arm: The firm plays a fundamental role in deal sourcing and market trend analysis based on their proprietary data platform. Currently, the firm is most interested in companies based in USA, Israel, and Western Europe, particularly companies in the Nordic region.
The firm will consider therapeutics, medical devices, diagnostics, and life science tools. The firm is most interested in medical devices, and their interests include medtech and biotech combination products, novel methods of drug delivery, in vitro diagnostics (novel instruments and reagents), etc. The firm is interested in both 510K and PMA devices. Within therapeutics, the firm is more interested in clinical assets and typically do not look at pre-clinical companies unless the opportunity is compelling. Current main indication areas of interest for the firm are cardiovascular disease, oncology, and women’s health.

The firm seeks to work with management teams who are passionate about their technology and dedicated to creating values for the larger community. Though the firm is able to support companies who are interested in entering the China market, having a China angle is not necessary for investment. The firm can act as either a lead or co-investor.

If you are interested in more information about this investor and other investors tracked by LSN, please email mandates@lifesciencenation.com.

Hot Investor Mandate: USA-Based Investment Firm Pursues Technology-Based Seed to Series C Life Science & Healthcare Companies

14 Sep

Through a network of strategic limited partners that includes leading providers, payers, and vendors, a USA-based venture capital platform applies industry knowledge and operational experience to early-stage companies focused on innovation. The firm’s most recent fund actively pursues Seed, Series A, Series B, and Series C stage investments. The firm’s exclusive focus is helping to transform healthcare by forging partnerships among its network members and the entrepreneurs addressing the industry’s biggest challenges and opportunities.

The firm pursues venture-stage investments in technology-based businesses in the healthcare sector, including but not limited to software, software-as-a-service, digital health solutions, technology-enabled services, clinical services, diagnostic tools, and medical devices. As an experienced life-cycle investor, the firm actively pursues Seed, Series A, Series B, and Series C stage investments.

The firm looks for privately held companies with experienced management teams. The firm looks to work side by side with entrepreneurs helping them form strategic relationships, recruit management talent, and assemble vital resources necessary for growth.
If you are interested in more information about this investor and other investors tracked by LSN, please email mandates@lifesciencenation.com.

Hot Investor Mandate: VC Firm Invests Up to $20M Novel Therapeutics and Medical Devices, With a Strong Focus on USA-Based Companies

14 Sep

A venture capital firm with several offices throughout the US has raised five investment funds since inception. Its most recent fund closed in 2021. The firm typically makes equity investments in U.S.-based companies, with portfolio companies located on both coasts and throughout the central part of the country. The firm will consider investing at all stages, with a focus on seed and early-stage investments, including founding companies. Investment size is up to $20 million throughout a portfolio company’s path to liquidity.

The firm is currently looking for new investment opportunities in the life science space, with a specific focus on biopharmaceuticals and therapeutic medical devices. The firm has invested in biopharmaceutical companies focused on developing drugs to treat enteral feeding intolerance and disorders that are driven by CD47-mediated signaling pathways, including leukemia, lymphoma, solid tumors, and pulmonary hypertension. In addition, the firm has invested in a medical device developing a minimally-invasive, catheter-based device to re-create valves in deep leg veins. The firm does not look at diagnostics, though may be interested in technology with real-time feedback for procedures.

The firm focuses on identifying and shaping early-stage life science companies in the series A/B rounds to create significant shareholder value. Because of its extensive operating expertise, the firm is able to help entrepreneurs achieve near-term objectives that position their companies for exit.
If you are interested in more information about this investor and other investors tracked by LSN, please email mandates@lifesciencenation.com.

Presenting the RESI Boston September 2023 Program Guide

7 Sep

By Dennis Ford, Founder and CEO of Life Science Nation, Creator of the RESI Conference Series

I am thrilled to present Life Science Nation (LSN)’s Program Guide for RESI Boston, September 18-20 at the Boston Park Plaza, Back Bay, Boston. This will be a hybrid RESI event, face2face September 18, followed by virtual partnering September 19-20. The Program Guide takes you through our investor panels, sponsor workshops, exhibitors, and 50+ Innovator’s Pitch Challenge companies participating in this RESI. RESI Boston attendees represent the leaders, innovators, and who’s-who of early-stage drugs, devices, diagnostics, and digital health (the 4 Ds).

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(Click Here to View the Digital Copy of Program Guide)

Early this week, I met with Daniel Levine for a Big4Bio podcast. We talked about what makes the RESI conference series unique, the critical role of conferences in today’s environment, and how early-stage founders and CEOs can make the most of their time at these events.

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It is not too late to attend if you are seeking capital investment or licensing opportunities. We hope to see you next week! Register today.

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