Global Investors are Increasingly Important to Life Science Startups

By Lucy Parkinson, VP of Investor Research, LSN

There’s a common perception that if you’re raising money to finance a life science startup, your best bet is to fundraise from local investors, such as a nearby angel group or a regionally focused VC.  While these groups are valuable in supporting innovation, it’s vital to look globally for potential investors for your company, because global investors are increasingly looking for you.

Life Science Nation’s core mission is to bring early stage startups together with early stage investors, strategic players and channel partners, and we are finding increasing traction for these efforts at a global level.  LSN’s Investor Research team speaks to investors all over the world about what areas of life science they are focused on investing in and what criteria they have, including geographic restrictions.  Of the investors from whom LSN has gathered active mandates, nearly 40% have no geographic restrictions at all; many more invest across continents, such as cross-border investors who focus on both Asia and North America.

It’s no coincidence that LSN is increasingly speaking to these groups; to cite one specific cross-border situation, in 2017 and 2018 investors from China accelerated their allocations to US-based biotech companies, according to Pitchbook. 

To serve this increasingly international community, LSN held our first RESI Europe event in March, bringing together hundreds of investors and startups – not just from across Europe, but also from the USA, Asia and beyond.  In November, we will be hosting our first RESI Asia events.  As LSN’s global ecosystem becomes richer due to these efforts, an increasing number of international investors are coming to all of our RESI partnering events, including the upcoming RESI Philadelphia.  This means that startups attending RESI can tap into this vast pool of international capital that’s looking for novel healthcare technologies, and can make global connections face to face in RESI Partnering.

The Battle with Balancing Authenticity

By Dennis Ford, Founder & CEO, Life Science Nation; Creator of RESI Conference Series

I cannot tell you how important it is to be authentic in the world of a startup, especially if you are going to try and raise capital or find partners who have channels for your product. The big challenge for most scientist entrepreneurs is that they are typically deep into their chosen field of endeavor and being so “deep in” causes some to lose perspective with their positioning in the current market. Let’s just say that this form of tunnel vision can leave you lopsided when you need to be balanced in your perspective when in dialogue with future partners.

It is understandable that the entrepreneur becomes overly engrossed in their products and technologies and is quite common – no one is going to be more passionate about your product than you are, and investors want to see passion. However, being in too deep can leave you out of context. I cannot tell you how many times I have meet a startup CEO who has a challenge carrying on a conversation outside their domain of expertise. They are so engrossed in all things relating to their technology and have difficulty adjusting or normalizing to the level of a non-expert. Try to remember that always going “deep in” makes the conversation one-sided and not understandable to the listener. This leaves the listener just trying to guess what this person is saying, with the entrepreneur potentially unaware that they have lost the listener and both are out of context. An entrepreneur has to maintain a balance, giving a technical explanation, but doing it in a way that a non-expert can understand. Also, appearing too absorbed in your technology can have other negative side effects – investors need to know that you can impartially determine the value and marketability of your products and that you can put together a team that can build a company, not just continue to do research.

All this begs the question: can you be too authentic? The answer is yes – if you lose perspective and stay totally absorbed in your technology, you will not be able to get out of your own way. Part of the conundrum is that to get to a point where you have a breakthrough product or technology, you have to commit and immerse yourself into the arena. However, you cannot go so far down the rabbit hole that you wind up in your very own entrepreneurs wonderland.

Perhaps now you can see why I decided there is a need to have this type of seemingly esoteric conversation with thousands of founders who are scientists and engineers “deep in”. Being deep in means you are authentic with your knowledge and expertise, but the other side of the authenticity coin is being able to honestly translate your knowledge and visions to the rest of the world with the proper perspective and complete business understanding. It is one of the key challenges you, the entrepreneur, will face. To bridge the inventor’s world with the rest of the world is to find your entrepreneurial voice.

Hot Investor Mandate: Family Office Investment Vehicle Seeks Disruptive Therapeutics, Medical Device, and Diagnostic Technologies Serving Unmet Medical Needs

A family office investment vehicle representing the interests of USA East Coast based family offices, is looking to invest in ground-breaking life science and medical device technologies. While the firm is very flexible in terms of investment size, they are generally looking to invest a minimum of $0.5 million per round. The firm is open to Investing in companies located throughout North America and Europe.

The firm is looking for breakthrough technologies with a strong social ethos in the Therapeutics, Medical Devices, and Diagnostics Sectors that address underserved medical needs or provide innovative and disruptive approaches to common medical procedures and treatments. The firm invests on an opportunistic basis and is especially interested in areas of intersecting technologies, such as nucleic acid-based drugs and delivery, regenerative medicine and cell-based therapeutics. The firm is less interested in small molecules and generally will not consider biosimilars or other technologies for which there is already multiple therapeutic options. The firm is looking for niche disease areas where disruptive therapeutics have the potential to be truly disease-modifying, not just provide symptomatic relief or palliative care. The firm typically is interested in preclinical stage assets that have well-developed animal model dossiers to Phase II or early Phase III stage assets. The firm’s investment mandate particularly focuses on “smart” clinical trial formats such as adaptive trials and Master Protocol trials for capital efficiency. For devices, the firm is looking for devices that address and perhaps substitute for a pharmacologic in a given therapeutic market, such as deep brain stimulation technologies and orthopedics. The firm is generally not interested in cardiovascular disease or diabetes.

The firm is currently reviewing co-investment opportunities in private companies and on an opportunistic basis, considering investment in micro-and small-cap public companies as a direct investor.

If you are interested in more information about this investor and other investors tracked by LSN, please email mandates@lifesciencenation.com.

Hot Investor Mandate: Korea Cross-Border Firm Actively Invests in Technologies that Address Oncology, Immunology, and Liver Disease Areas

A Korea-based investment firm manages several funds that focus primarily on the small- and mid-cap market in Korea, with around $500M AUM. Recently, the firm has closed a biotech-focused fund that will invest in global start-ups. The firm’s size of investment will depend on the stage of the company and will actively engage in follow-on investments as well. The firm actively seeks global opportunities.

The firm invests broadly across therapeutics, medical devices, and diagnostics, with the strongest interest in therapeutics. The firm is open to all types of modalities and is most interested in oncology and immunology indications as well as liver diseases such as NASH.

The firm seeks management teams with strong scientific expertise and experienced management teams. The firm may act as either a lead or co-investor and will not require a board seat post-investment.

If you are interested in more information about this investor and other investors tracked by LSN, please email mandates@lifesciencenation.com.

Hot Investor Mandate: China VC/PE Firm Invests Up to $15M in Promising Therapeutics and Medical Devices with Strong China Market Opportunity

A venture capital/private equity firm based in Shanghai, China. The firm manages both US and RMB denominated funds. The firm invests in Series A rounds at $1-2M, though its sweet spot is investing $10-15M in Series B/C rounds. The firm works closely with local provincial Chinese governments, allowing them the ability to bring technology successfully into the Chinese market. The firm will generally not invest in the seed stage, and seeks opportunities globally.

The firm invests in pharmaceuticals and Class II (510k) medical devices, including an interest in 505(b)(2) repurposed compounds, as well as healthcare-related industries. The firm is interested in all therapeutic areas and in early to mid development stage companies. The firm focuses on unmet medical needs with a China market potential.

The firm does not have management team requirements. The firm will typically take a board seat post-investment, and has the capability to lead and co-invest.

If you are interested in more information about this investor and other investors tracked by LSN, please email mandates@lifesciencenation.com.

Hot Investor Mandate: VC Firm with USA & Canada Offices Actively Seeks Investment Opportunities in Drug Delivery, Diagnostics, Platform Technologies

A venture capital firm with offices in USA and Canada is considering opportunities for investment out its third, most recent fund. The firm leads or co-leads seed investments, typically in the $500K-$1.5M range, in seed – small A rounds, and will provide additional capital to portfolio companies of up to $8M from the primary fund and up to an additional $8M from the LP co-investment fund, over the life of the investment. The firm looks to make 3-5 investments per year.

The firm has invested in a variety of med-tech companies including a company with a drug delivery platform technology and a range of digital health companies. Moving forward the firm will be more focused on diagnostics, drug delivery and platform technologies capable of generating re-purposed drugs – emphasis placed on short sales cycles and de-risked assets. The firm is agnostic in regards to therapeutic type and will consider large and small molecules as well as re-purposed or biosimilar assets and platform technologies. The firm prefers to invest early in a therapeutic’s life cycle, typically in preclinical or phase I, and is opportunistic in terms of indication.

The firm only considers companies with experienced management teams, and requires a board seat with every investment.

If you are interested in more information about this investor and other investors tracked by LSN, please email mandates@lifesciencenation.com.

Don’t Wait! There is Still Time to Apply to RESI Innovation Challenge. Deadline May 1st…Go for It!

By Gregory Mannix, Vice President International Business Development, LSN

The deadline to enter the RESI Innovation Challenge for the RESI Philadelphia event (June 3rd) is fast approaching, coming up May 1st. I would encourage every fundraising CEO and scientist/entrepreneur who will be in Philadelphia in early June to go for it! The RESI Innovation Challenge is a great way to instantly get your company from regional mode to global mode as RESI Philly is going to be loaded with international biotech, medtech and digital health partners and investors. A great strategy is to apply for the Innovation Challenge and if you are one of the 35 early stage startups selected, you can use that prestigious selection to help garner more partnering meetings. We are expecting over 300 investors in attendance at RESI, and the ratio of investors to startups is typically 1 to 1. These global investors and partners come to RESI seeking innovative technologies with high potential to scale in global markets. The RESI partnering system is designed to ensure that meetings between investors and startups are based on a strong fit for each other’s criteria, and we have often heard that makes RESI a much more productive place to meet than other events.

We encourage all applicants to read our article on How To Be Successful in the RESI Innovation Challenge. There is not much time left to apply – interested applicants, please complete your online application through our application portal here or submit your PDF application and supplementary materials by sending them to RESI@lifesciencenation.com. We look forward to receiving your submissions!  Here is a list of the companies that placed in the top three at the last 4 RESI events.  Take a look at the companies who have won in the past – they represent a very compelling and diversified group of technologies.

Company Description of Technology Location
Miniaturized auto injector for patients who need to carry emergency injectable medications North Carolina
Light emitting swallow-able capsule for treating Chrome’s disease Israel
Electronic Catheter Guidance System England
Online speech tele-therapy solutions Israel
Medical devices for ICU monitoring Taiwan
Revolutionizes blood flow imaging through PET scanning Denmark
Doctors office  MRI imaging California
NICU feeding management and lactation analytics Pennsylvania
Minimally invasive device for treating post surgical pain Pennsylvania
Micro-machine for monitoring and treating ventricular heart conditions Massachusetts
Novel brain imaging for monitoring sedation Massachusetts
Noninvasive devices for monitoring and treating hypertension and migraine headaches California