Archive | March, 2013

Hot Life Science Investor Mandate 3: Family Office Seeks Opportunities in Medtech Space – March 28, 2013

26 Mar

A family office located in the Western US with around $100 million in assets is looking for a compelling opportunity for allocation within the next 6-9 months. The office invested in more than five deals in 2012, typically between $1-5 million per firm.

The foundation is most interested in medical devices, and will look at firms within the full gamut of medtech subsectors. Typically, the office allocates to firms that have at least one product on the market. They have no strict criteria in terms of a firm’s EBITDA or revenue, but require that any firm in which they invest has goals to lower the cost of healthcare.

The Mantra and Myths of Capital Efficiency

26 Mar

By Danielle Silva, Director of Research, LSN

As time-to-exit has become protracted for life science investments in recent times, capital efficiency has become somewhat of a buzzword in the industry; but it seems that many firms still struggle with understanding not only what capital efficiency is in the context of the life science space, but also how to demonstrate it to potential investors. In the past, many young life science companies believed that more is always better – the more capital raised the better, and in turn, the bigger their valuation the better. Just because a firm is able to raise more capital does not mean the firm has in turn increased value for the firm’s stakeholders.[1]

It is still important for life science firms to constantly be in fundraising mode in order to keep an ongoing dialogue with potential investors, and companies still need to be cognizant of the fact that they need to raise money in order to get to the next round of funding. However, life science companies need to keep in mind the mantra of capital efficiency – doing more with less – creating more value with less capital, which is what life science firms need to focus on in order to both gain investor interest and create value for their investors.

Often, when investors refer to firms that do not have a “capital efficient” model, they point out firms that have been able to raise a good amount of capital in a small amount of time. Raising a huge lump sum is not always a bad thing – but if firms aren’t able to provide any returns to shareholders on the huge sum invested, then receiving this large allocation does prove to be problematic. Firms that aren’t able to illustrate that the investment has created any value will have trouble raising money in subsequent rounds, even if they are somehow able to show that there is a dire need for the capital.

Capital efficiency also plays a huge part in driving down the cost of capital over time – which is something life sciences firms also need to keep in mind when raising capital, considering the relatively large number of financing rounds required before product reaches marketability. Your firm needs to create more value with your cash on hand than your burn rate. If you don’t follow this rule, then subsequent financings will continue to dilute your company’s value.

The major question for life science companies, then, is how to achieve capital efficiency and how to demonstrate it to potential investors. One way to improve capital efficiency is to simply gain an understanding of the cost it will take to get to market – this includes what regulatory risks/costs may be associated with developing the technology and the firm’s target market for the product. Understanding the risks and the market will help the firm to more accurately identify if their firm is being overvalued or undervalued – again, if the firm is overvalued it will exacerbate problems with obtaining follow-on funding and raise the cost of capital in the long run.

Another useful concept that life science companies need to keep in mind is that time is money – if failure is inherent, then the firm needs to be able to quickly change their strategy and be able to identify an alternative market, indication, or application for the technology being developed. One of the most important aspects of capital efficiency is to be efficient on an operational level; firms need to leverage their existing capital base and if possible monetize their non-core assets at an early stage.

In order to prove that your firm is capital efficient, you will need to provide potential investors with financial statements, as well as outline your team. Illustrating that you have hit key milestones with a lean staff is an integral part of demonstrating capital efficiency to investors. Additionally, if your projected infrastructure expenditures or current spending to operational spending exceeds a ratio of 1:1 then this will be a huge red flag to investors.[2] Furthermore, to illustrate capital efficiency, it is important to make multiple projections for regulatory costs to show investors that you have already thought about the best and worst case scenario for getting the product to market.

If all these factors are taken into consideration by life sciences firms, it can help a company to become much more capital efficient. In the end, for life sciences firms and investors, capital efficiency is a win-win – the cost of capital is reduced for life science companies, and the return on investment is greater for investors. Thus, moving forward in order to attract investor capital life sciences firms will need to adopt the mantra of capital efficiency. If there is one thing you keep in mind – you will always need twice as much money and time as you think, and there will always be bumps in the road. Plan for it, and you are immeasurably closer to success.

PE Actively Hunting Investment Opportunities in CROs

26 Mar

By Alejandro Zamorano, VP of Business Development, LSN 

As of late, LSN has seen a dramatic uptick in the number of investors focusing on allocations to service providers. It is evident that the appeal stems from two fundamental factors: first, service providers provide less investment risk to investors relative to companies developing therapeutics, diagnostics and medical devices, as they can generate cash flow quickly by avoiding exposure to regulatory approval. Second, service providers’ growth is boosted by taking advantage of big pharma’s appetite to outsource non-core competencies, such as assay development, toxicology, clinical development, and manufacturing service providers. As a result, service providers are in a golden age of opportunity.

As evidence, for the past two years, some of the industry’s largest service players have been on a hiring spree in order to support their increasing workflow. Forbes reported recently that, in a poll of 388 drug makers and biotechs, CRO clients saw a 9% increase in outsourced R&D budget, with total market penetration by CROs increasing from 35% to 38%. Among large drug makers, 27% expect to outsource, while 47% of emerging biotechs are expecting to outsource. This growth trend bodes well for an industry that is largely insulated from the risk that plagues the rest of the industry, and allows investors to take some advantage of macro trends without the downside of exposure on a therapeutic asset level.

All service providers, however, are not created equal. Service providers focused on preclinical development are projected to have the lowest growth prospects in the short term as they suffer from the declining R&D budgets. Clinical service providers like Parexel and Icon are projected to have the strongest growth with revenues projected to grow by over 12% for next three years. Despite the apparent abundance of service providers, the industry is currently just barely keeping up with demand.

Private equity has the most appetite for service providers in the life science, as their large capital investment can significantly expand the marketing and sales efforts of small operations leading to substantial returns. By using the added capital, service providers can also expand their service portfolio, adding to new revenue opportunities.

Three Hot Investment Areas in Medtech for 2013

26 Mar

By Max Klietmann, VP of Marketing, LSN

As we come to the close of Q1 of 2013, LSN has compiled some insight into three of the hottest subsectors being targeted by investors in the medical technology space. New technologies are surfacing that are changing treatment philosophies, and more importantly, medtech is attracting a whole new class of investors such as corporate venture from the consumer electronics, digital media, and telecom space. Here are the three trend areas that are changing the world from the medtech investor perspective:

Personalized medicine

As med tech becomes more complex, it is becoming easier to create patient-customized technologies. This allows treatments to be developed that target specific subgroups of patients within a disease area. The idea is to create better outcomes by tailoring therapy. We’ve spoken about this at length with regard to biopharmaceuticals, but this is taking place in the med tech space as well. It is occurring both in the form of devices that can be customized, as well as in the diagnostic/health IT space. For example, big data and cloud computing are being used in combination with genomics. For under $100, a patient can be screened for over 275 biomarkers, which when run through complex algorithms and predictive models, are helping to create custom treatments. This allows for scalable tailoring of therapy on a patient-by-patient level, resulting in better outcomes with fewer side effects. Investors find this attractive, due to the innate advantages offered, and the scalability of many of these technologies.


Biochips are becoming an extremely hot area, especially in the screening space. They are being developed for diagnostic and monitoring purposes, and are being heavily focused on with regard to accurate biomarker measurement. Biomarkers are substances that indicate a particular indication or biological state in a patient, and increased accuracy in their measurement means earlier diagnosis, more targeted therapy, and better outcomes for patients. Again, the ability to significantly improve outcomes in a scalable way has investors excited about this technology.

Mobile-Enabled Active Implantable Devices

Active electronic implants are old news, but what’s new is that these devices are beginning to get smart – the integration of mobile technologies into devices is creating a whole new marketplace within the device space. For example, pacemakers and insulin pumps are already being fitted with mobile technology to allow physicians to monitor patients remotely, compile data on large populations, and diagnose problems / recommend treatment before the patient is even aware. This area is attracting a lot of attention from non-traditional investors, including mobile and telecom corporate venture.

Things are changing fast in medtech and savvy investors are moving fast to dig up the hottest opportunities across the board. Keep your focus on these areas, as they are likely to heat up heavily over the next few quarters.

Hot Life Science Investor Mandate 1: Government Provides Foundation Nearly $2b to Fund Sustainable Tech – March 28, 2013

25 Mar
A government foundation in North America that was created to provide funding for novel technologies has been provided $1.9 billion in assets to further this mission.

The foundation is currently looking for new firms in the life sciences space for potential allocations. Although they do not have a set number of firms they wish to allocate to over the next six to nine months, they typically will provide capital to around 20 firms annually. With that being said, they will allocate to a number of firms over the next 6-9 months if some compelling opportunities are uncovered.   Currently, the foundation is most interested in the biotech space, specifically in firms focused on environmental biotechnology. In particular, the firm is seeking firms that are developing anti-pollution or waste remediation technologies.

The foundation is only looking for companies that are pre-revenue, and thus provide seed funding to these. The foundation is willing to provide up to one-third of the capital required to develop the technology. However, they must demonstrate that they will be able to obtain funding for the remaining two-thirds of the financing.

Hot Life Science Investor Mandate 2: VC in Eastern US Looking for Biotech R&D for New Allocations – March 28, 2013

25 Mar

A venture capital group based in the Eastern US has around $200 million in assets, and is currently deploying capital from its second fund, which has approximately $150 million in assets. They are currently looking for new investment opportunities in the life sciences space, and plan to invest in 2-3 new firms within the next six to nine months.

The firm allocates $1-10 million per investment, and the majority of its investments are in the $5-10 million range. Currently, the VC is most interested in biotech R&D services firms, and is seeking contract manufacturing organizations (CMOs) and contract research organizations (CROs).

Their primary mandate is for biotech firms whose primary customer base are biotech therapeutic and diagnostic firms, as well as pharmaceutical companies. The firm prefers companies that have at least $2 million in revenue, but prefers firms in the $5-30 million range.

Hot Life Science Investor Mandate 3: PE Group Ready to Deploy Capital to Firms Developing Medical Devices – March 26, 2013

25 Mar

A private equity group based in the Eastern US has around $800 million in total assets under management, 30% of which are dedicated to the life sciences space. The firm is currently looking for new opportunities within the life science sector, and while they have no set time frame to make an allocation, they would invest in a company within the next six months if a compelling opportunity were uncovered.

The firm is most interested in the medtech space, specifically in firms developing medical devices. The PE only invests in firms that have products that are on the market, and prefers that they have $2-20 million in EBITDA and $10-100 million in revenue. The firm typically makes investments of $2-60 million in the form of subordinated uni-tranche debt. The firm will consider both private as well as smaller public companies.