Archive | September, 2015

Hot Life Science Investor Mandate 1: Australian Family Office Looking for Therapeutics and Medical Devices with Clinical Data

10 Sep

A family office based in Sydney, Australia focuses on therapeutics and medical devices that are past pre-clinical trials. The firm currently manages a $2.5 billion evergreen fund, and typically invests between $1 and $10 million. The firm normally makes co-investments in the USA, Europe, Israel, and Australia. The firm does not invest in companies based in Southeast Asia.

The firm is currently looking for new investment opportunities in therapeutics and PMA medical devices. The firm is particularly interested in peripheral blood-based colorectal cancer diagnostics, but is not open to diagnostics in any other subsectors or indications. The firm is open to all subsectors and indications in therapeutics and medical devices, though is not interested in software-enabled devices or lab equipment and drug development enabling technology. The firm does not invest in pre-clinical products, and only seeks products that are either in clinical trials with human data or on the market.

The firm seeks companies with an established management team with experience in the field. The firm does not typically take a board seat after an investment. The firm seeks distribution rights for Australia and Southeast Asia from international companies.

If you are interested in more information about this investor and other investors tracked by LSN, please email mandates@lifesciencenation.com

Hot Life Science Investor Mandate 2: Canadian VC Seeking Wearable Medical Devices

10 Sep

A Canada based venture capital firm looks to make investments of approximately $5 million with reserves left for follow on rounds. The firm looks to make one new equity or debt investment per month and gives preference to companies located in North America but is open to Australia and Western Europe depending on the opportunity. The firm does not request distribution rights for international investments.

The firm is interested in early-stage wearable technology, software-enabled medical devices and any technology that can improve hospital operations. The firm does not have any revenue requirements for wearable technology and the firm is open to regulatory products. The firm is looking for both in-development and clinical stage devices and will consider investments in healthcare IT companies as long as the company is already established with positive cash flow.

The firm values sweat equity but the firm will not make any investments into a company unless the founding team has invested their own funds into the company’s success. The firm takes a board seat when making any new investments and looks for strong, experienced management teams. The first question the firm will ask any new opportunity is whether or not they have experience in marketing, sales, startups, or the industry they are entering. The firm can provide strategic management if necessary.

If you are interested in more information about this investor and other investors tracked by LSN, please email mandates@lifesciencenation.com

Hot Life Science Investor Mandate 3: Corporate VC Fund of Global Healthcare Company Seeking Innovative Therapeutics, Devices and Diagnostics in a Number of Indication Areas

10 Sep

The corporate venture fund of a multinational healthcare company has allocated CHF 500 million to invest in and develop commercially successful innovative life science companies. The fund is an evergreen fund and makes equity investment in early-stage biotech therapeutic and diagnostic companies. The fund prefers Series A. The typical initial investment size ranges from CHF 1-5M with capital reserved for follow-on financing. The fund invests in companies that are based in Europe, North America, and the Pacific Region. The fund is actively seeking new investment opportunities.

The Fund is looking to invest in companies with innovative new technologies, medicines or diagnostics, particularly in the areas of interest to the fund’s parent company. This includes: Oncology, Central Nervous System, Inflammation, Anti-Infectives, Virology, in-Vitro Diagnostics, Diabetes Care, and Molecular Diagnostics. For therapeutic biotech, the fund is willing to invest in companies that are still 18-24 months away from the clinic. The fund highly prefers companies with both a discovery engine and a product pipeline.

The Fund invests in private and public companies. The fund only invests in public companies as part of a collaboration entered into by the parent company’s pharma or diagnostics division. The fund requests board seats and typically prefers to be in an ownership range of 15% or more. In general, the fund prefers to co-invest with leading venture funds as well as other corporate venture funds.

If you are interested in more information about this investor and other investors tracked by LSN, please email mandates@lifesciencenation.com

Hot Life Science Investor Mandate 4: Global Pharmaceutical Company Seeking Early Stage Partnerships in Immunology, Inflammation and Metabolic Diseases

10 Sep

A global pharmaceutical company is looking to form partnerships with small biotech companies using a variety of structures depending on the needs of the opportunity, including licensing, development partnerships, co-marketing, and acquisitions. Partnerships may also involve in-kind services. The firm works with partners worldwide.

The firm is currently looking opportunistically at novel therapeutic assets. While the firm will consider assets in any indication area, immuno-oncology is an area of high interest; the firm is also particularly interested in other areas of immunology and in inflammation, metabolic disease (particularly type 2 diabetes), fibrosis and hypertension. The firm is open to any type of modality, including small molecules, biologics or cell therapies. The firm also has some interest in companion diagnostics and means of selecting suitable patients or monitoring patients. The firm will work with companies at any stage of development, from very early discoveries through to market.

The firm does not work with companies pursuing incremental innovations; the firm only partners on novel, breakthrough technologies, such as new molecules or new targets. The firm is interested in assets in which the mechanism of action is understood, and it is preferred that the target or pathway of the asset is validated. The firm is interested in assets that have been shown to have an unambiguous advantage, and which can create value for patients and payers.

If you are interested in more information about this investor and other investors tracked by LSN, please email mandates@lifesciencenation.com

How to Write a Compelling Partnering Message

3 Sep

By Alejandro Zamorano, VP of Business Development, LSN

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Life Science Nation attends many partnering conferences, in addition to hosting our own quarterly Redefining Early Stage Investments (RESI) Conference series. After taking the time to study the most successful partnering requests and interviewing investors about what they look for in an introductory note, we have created a template email, which should increase your response rate when soliciting investment:


Frank,

My name is John Doe, CEO, Sample Therapeutics, an early stage therapeutic company based out of New York developing an antibody drug conjugate (ADC) for pancreatic cancer. Our lead asset (OK-101) is in the middle of Phase 1 clinical trials and is open to partnership opportunities.

OK-101 leverages Sample Therapeutics’ proprietary ADC technology to deliver doxorubicin to cancer tissue more efficiently, thereby reducing toxicity and increasing its efficacy. Unlike traditional ADCs, Sample Therapeutics’ platform uses a two-part ADC system in which antigen-specific antibodies are injected into the body first, followed by the small molecule that then binds to the antibodies in the cancer tissue. This system increases the versatility of known ADC technology and avoids the common liver toxicity problems found in traditional systems.

Currently we are at the beginning stages of our fundraising campaign to complete our Phase 2 by Q4 2016. Given your firm’s experience in clinical stage oncology assets, and what I read in your profile our company seems to match your investment interests.

I think we are a good fit for your investment strategy and would like to have an opportunity to connect with you at the RESI Conference.


Let’s break down the email in order to understand its structure.

1st — Introduce Yourself

Introduce yourself, your title, and the name of your company. Although obvious, you might be surprised by how many people don’t do this.

2nd — Introduce Your Company

Give a brief overview of your company so that an investor can determine from the first sentence whether you are a fit for their investment mandate. Remember, every investor is unique and therefore not every investor is a fit for your opportunity. Here are five key data points that are likely to affect investor fit:

  • Where your company is based
  • What sector your company is in (biotech, medtech, diagnostics, healthcare IT, etc)
  • The modality you are using
  • The indication you are treating or problem you are trying to solve
  • Your product’s development phase

3rd — Key Value Proposition/Elevator Pitch

Use the next part of the email to describe the key value proposition of your technology. This should include a high-level description of the core technology and its major differentiators from currently available products or solutions. This is the core of your messaging and should reveal enough information to pique interest.

4th — The Stage of Your Fundraising Campaign

You should clearly state where you are in the fundraising process (beginning, middle or end) and what the use of those proceeds will be. This way an investor can gauge if your round is a fit for their capital allocation.

5th — Reaffirm

You should do your homework on every investor you reach out to and reference a relevant data point to reaffirm the reason you are reaching out.

6th — The Next Step

Finish the email by laying out when you plan on connecting with them and how the both of you should connect. As this is a conference partnering message, this can be as simple as telling them to accept the meeting request if they would like to meet up.

By sticking to these fundamentals you will make it a lot easier for an investor to identify you as a fit for their investment strategy. This will lead to higher response rates and more productive meetings.

RESI Panel Announcement: Preclinical & Phase I Investors, Investing Early in Novel Therapeutics

3 Sep

By Lucy Parkinson, Senior Research Manager, LSN

If you’re developing a biotech asset and you’re raising funds in order to complete pre-IND studies, or to embark on your first human clinical trial, this panel will provide an opportunity to hear from investors who focus on companies at this challenging stage of the development process.

Moderated by Steven Gullans, Managing Director, Excel Venture Management, this panel features:

These investors will offer their insights on the challenge of assessing a biotech opportunity prior to attaining human proof of concept data. What factors do they consider indicative of future success? Which fields of technology are the most promising for early-stage biotech investment today? How do you demonstrate the value of a new breakthrough product to a potential investor? We’ll look forward to hearing the panel’s insights on these and other vital questions faced by Preclinical and Phase I biotechs.

Summer Reading Series Final Issue: The View Beyond Venture Capital

3 Sep

By Michael Quigley, Director of Research, LSN

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To wrap up the entire Summer Reading Series we bring you an article we wrote for Nature Magazine entitled “The View Beyond Venture Capital”. This piece discusses many of the shifts that are currently taking place in the life science investment ecosystem including the rise in relevance of family offices for early stage life science companies, different types of investor mandates, the changing role of Big Pharma, and more.

Click here to download/print the chapter PDF

It has been our pleasure to share these past 15 issues of the LSN Summer Reading Series with you and we hope you found some practices to bring back to you own campaign. If you missed out on any chapters thus far here are the links!

Enjoyed the preview? Buy now from Amazon.com or Barnes & Noble

Bookcover-Front