Tag Archives: Life Science

Hot Life Science Investor Mandate 2: European VC Interested in Wide Range of Biotech & Medtech Opportunities – March 14, 2013

12 Mar

A venture capital fund based in Denmark has over €700 million in total assets under management, and has raised three funds. The firm is currently deploying assets from its third fund, which closed in 2011. The third fund’s portfolio currently consists of four companies. They are unsure of how many transactions they will execute in 2013, but aim to have ten to twelve companies in their portfolio for their third fund, and thus would invest in a firm over the next few quarters if a compelling opportunity is identified. Their typical equity check ranges from €6-10 million.

The firm is looking for companies in the biotech therapeutics & diagnostics space, and the medtech space. The fund invests in both therapeutics & diagnostics, and will consider the full gamut of subsectors and indications within the biotech therapeutics and diagnostics, as well as in the medtech space.

The VC invests in pre-revenue, early stage companies. With that being said, they are solely looking for companies that do not currently have a product on the market. In the biotech therapeutics and diagnostics space, the firm typically prefers to invest in companies one year prior to the firm starting their phase I clinical trials. In the medtech space, the firm looks for companies that have a prototype of their device.

Hot Life Science Investor Mandate 3: Private Equity Fund Targets Contract Organizations for 2013 – March 14, 2013

12 Mar

A private equity fund based in the Eastern US has around $200 million in total assets under management, has raised three funds, and is currently allocating capital from its third fund to new investment opportunities. They are currently looking for new opportunities in the life science space, and anticipate on investing in 4-6 firms in 2013. The firm typically writes equity checks ranging from $15-50 million.

The PE fund is currently most interested in firms within the biotech R&D space. Specifically, they are looking for contract research organizations (CROs) and contract manufacturing organizations (CMOs). The firm also invests in the medical device space, but prefers firms that are manufacturing low-technology products. The firm is agnostic in terms of where the firm is based, however the majority of the firm’s current portfolio companies are based in the US.

The firm engages in leveraged buyouts, recapitalizations, and growth financing. Typically, they work with companies whose enterprise value ranges from $25 to $300 million, and are looking for firms that have at least $5 million in EBITDA. However, the PEG has been involved in co-investment tractions with enterprise values exceeding $1 billion. With that being said, they will only consider medical device companies that have products that are on the market, and would not consider a pre-revenue medtech firm. The firm invests in both public and private companies.

Hot Life Science Investor Mandate 1: Mezzanine Debt Fund Focused on Intellectual Property Investments – March 7, 2013

6 Mar

A mezzanine debt fund with offices in the United States is focused on structured financings of commercialized biopharmaceutical products and medical technologies. The firm’s total AUM is approximately $400 Million. They have collectively completed more than 50 royalty transactions representing more than $3 billion in capital over the past 15 years.

The fund is heavily invested in healthcare investing that focuses on intellectual property investments in FDA-approved biopharmaceutical assets through royalty bonds, structured debt, revenue interests and traditional royalty monetization. The firm targets investments between $20 and $200 million, and work directly with leading healthcare companies and research institutions.

Typical financings are intended to healthcare organizations fund pipeline development, make acquisitions, and expand into new markets—all with an adaptable source of capital. The firm’s primary source of collateral is derived from commercialized products.

Hot Life Science Investor Mandate 2: Government Organization has $2b to Promote Sustainable Tech Developments – March 7, 2013

6 Mar

A foundation that was created by the government of Canada in order to provide funding for technologies that promote sustainable development has been provided nearly $2 billion in assets by the Canadian government in order to further this mission. The foundation is registered as a non-profit, non-share capital corporation under the Canada Business Corporations Act. The government foundation has two funds, which have allocated over $1 billion together.

The firm is currently looking for new firms in the life sciences space for potential allocations; and although they do not have a set number of firms they wish to allocate to over the next six to nine months, they typically will provide capital to around 20 firms annually. With that being said, they will allocate to a number of firms over the next 6-9 months if some compelling opportunities are uncovered.

The foundation typically invests around $2-3 million per firm, but has allocated as little as $500,000 and as much as $40 million in the past. They are currently most interested in the biotech space, specifically in firms focused on environmental biotechnology. In particular, the firm is seeking firms that are developing anti-pollution or waste remediation technologies. The firm is only looking for firms that are pre-revenue, and thus provide seed funding to these firms.

Hot Life Science Investor Mandate 3: VC Group has Interest in CMOs, CROs – March 7, 2013

6 Mar

A venture capital group based in the Eastern US has around $200 million in assets, and is currently deploying capital from the firm’s second fund, which has $100+ million in assets. They are currently looking for new investment opportunities in the life sciences space, and plan to invest in 2-3 new firms within the next six to nine months. The firm allocates $3-10 million and the majority of the group’s investments are in the $5-7 million range.

The firm is most interested in biotech R&D services firms, and is seeking contract manufacturing organizations (CMOs) and contract research organizations (CROs). The firm is looking for biotech firm’s whose primary customer base is biotech therapeutic and diagnostic firms as well as pharmaceutical companies. The firm prefers companies that have at least $2 million in revenue, but prefers firms in the $5-30 million range. The firm solely invests in privately owned firms.

CRO Trends in 2013

6 Mar

By Alejandro Zamorano, VP of Business Development, LSN

A clinical research organization (CRO) is an organization that provides support to the pharmaceuticalbiotechnology, and medical device industries in the form of research services outsourced on a contract basis. These services can include assay development, preclinical research, clinical research, clinical trial management, and commercialization services. CROs have grown massively over the past 10 years due to their ability to specialize; allowing clients to streamline operations far beyond what could ever be accomplished internally. These firms tend to be highly capital efficient, and play the space strategically. A CROs survival is hinged on moving with industry changes. Below are the top behavior trends among CROs for 2013 as we continue to see strong growth in this often ignored sector:

Strategic Alliances

2013 will be the year of strategic alliances for the CRO industry. Big pharma is already picking sides, signing multiyear agreements with the industry’s big players. By forming partnerships, big pharma is able to negotiate prices and take advantage of key personnel within the company. In addition, big pharma can consolidate its operations and streamline communications, easing the burden of managing multiple service providers.

Investors

CROs have begun to take equity positions in lieu of cash for services rendered, especially among small and emerging clients. We will continue to see this trend grow as CROs move more heavily into the small and emerging biotech space due to competition and the potential opportunity to foster a long-term relationship. In addition to this, these specialized organizations can (and will) leverage their in-house expertise to invest in particular assets. This trend is also being facilitated by the fact that CROs want to diversify their exposure from a specific service class, and want to participate in the upside potential with unique clients. As an entrepreneur getting a discount off of preclinical work, Phase I or Phase II study is huge relief. In addition, this is appealing for the entrepreneur as it aligns the interest of the entrepreneur and the CRO. Finally, CROs tend take modest equity stakes depending on the work rendered and the phase of the lead asset, which is often more attractive than what entrepreneurs can yield in the market.

Emerging Markets
CROs will continue to expand their operations in China and India to take advantage of the cheap labor force, a more lenient regulatory environment, rapidly accelerating R&D, and advantageous tax treatments. It’s not just US and European-based companies relocating operations to these markets; over the past 5 years, native companies in these emerging markets have begun to make a splash. Often competing on price, these native operations have begun to put pressure on the market, decreasing gross margins across the board.

Globalization

With growing the therapeutic market in the emerging markets, countries are now requiring that native populations are included in clinical trials. As a result, clinical trial organizations have significantly grown in countries such as Brazil, Russian, Japan, China, and South Korea. As of 2011, around 53% of clinical trials were performed in the US, 24% in Europe, and 23% in the rest of the world. Looking forward we can expect the market share especially amongst the BRIC’s (Brazil, Russia, India and China) to grow. Analysts for example project the pharmaceutical market in China will reach $200 billion by 2020, making it the second largest in the world.

Developing Biosimilars

Large CROs are starting to team up with CMOs as they realize that by combining their economies of scale in the area of biologics, they have a perfect partnership to start developing bio-similars. Small biotechs have realized that developing biosimilars is harder than most would have expected. More importantly traditional generic developers are not equipped to handle the next generation of biosimilars. This has provided a perfect opportunity for CRO’s to fill in the gap.

 

http://www.fiercebiotech.com/story/rd-trends-spur-cro-business/2011-08-05

http://www.contractpharma.com/issues/2011-05/view_features/cro-industry-update-2011-04-29-10-53-51/

http://www.niceinsight.com/ni_it.php

http://www.contractpharma.com/issues/2012-06/view_features/cro-outlook-opportunities

What Investors Look for During the Due Diligence Process

6 Mar

By Danielle Silva, Director of Research, Life Science Nation

For life science investors, conducting thorough due diligence on potential investments is critical, especially because many investors in the sector invest in pre-revenue companies that do not have sturdy financial positions from which to court investors. There are many misconceptions that life science firms have about what will make or break an investor’s decision to provide capital. It is extremely important for life science firms to understand what factors will come into play during the due diligence process, and what they will need to demonstrate to a potential investor. It is also key to have a checklist of all the due diligence materials that they will need to have readily available to provide to investors.

Investors in life science companies have become increasingly cognizant of intellectual property (IP) issues, which often times are addressed during the due diligence process. If IP issues are ignored, it can ultimately decrease an investor’s return on investment (ROI), and cause legal issues for them in the future. Thus, potential investors will expect that startups be very transparent about their IP portfolio and will expect companies to disclose all information regarding the IP, including if the IP is protected (for instance if the firm has patents), what products or services are covered by the IP, if there are potential competing technologies, as well as regulatory and legal implications that could potentially affect the IP. Investors may also expect to be provided a number of documents pertaining to the IP during the due diligence process.

Often times, emerging firms will believe that if they are backed by a well-known incubator, the due diligence process will be less exhaustive than for startups which do not have this kind of relationship. If anything, investors will expect firms that work with an incubator to be even more polished than startups that do not have a relationship with this kind of firm, because incubators often provide startups with many resources to help them create a solid infrastructure.

Although business incubators are known to be selective in terms of the firms they work with, they typically do not conduct deep due diligence themselves (they typically just want to ensure that a firm will not be a liability in the long term). Thus, investors will still need to conduct deep research on the firm themselves, and speak with references that are not associated with the firm’s incubator. Working with an incubator, however, is still beneficial for startups, and may illustrate to a potential investor that the firm has a unique product or idea and that they’re putting in some extra effort grow the company and get a solid infrastructure in place.

Another myth that many entrepreneurs believe is that if their firm is registered as a Delaware corporation (DE corp) it will shorten the due diligence process. Although registering a firm as a Delaware corporation will certainly add legitimacy to a company (around half on the Fortune 500 list are registered as DE corporations), it unquestionably will not convince an investor to immediately give a firm their stamp of approval and make an investment. Firms can easily and inexpensively register as a DE corporation online (sometimes for as little as a several hundred dollars), so investors may be wary about a firm’s validity even if they do obtain this registration. Registering as a DE firm, however, is beneficial to small firms and should be taken into consideration because Delaware does have very favorable business laws. Thus having a DE corp registration will not make or break an investor’s decision, but it may help a firm demonstrate to an investor that the management team does have a level of business acumen.

Many life science firms recognize that they must spend a good deal of time and resources putting together their marketing materials and focusing on branding their firm to attract potential investors. Many firms, however, do not realize that in order to complete a deal with a potential investor, they must also have their due diligence materials in order. Accordingly, it is vital to put just as much time and effort into drafting due diligence materials as it is to spend valuable resources on putting together marketing materials.

Investors will expect that entrepreneurs will provide a number of documents during the due diligence process, regardless of how young the firm is. This will generally include all of the companies financials (including future forecasts), lists of employees, investors, and advisors (including legal representation), stock purchase agreements (as well as stock option and agreements and plans), articles of incorporation and by-laws, product plans, as well as a business plan and investor deck (if not already provided to the investor previously). This is not an exhaustive list of all the due diligence materials that investors may ask for, but these are the most common documents that investors will ask that a company provide.

The most important thing to keep in mind during the due diligence process (although quite obvious) is that honesty is always the best policy. If certain numbers are provided to an investor over the phone by a company during their initial correspondence and these figures do not match up when an investor is going through a firm’s financials during the due diligence process this will be a huge red flag for the investor. Thus it is imperative for entrepreneurs to be open and honest with investors from the get go, and to be as transparent with investors as possible. This will not only ensure that an investor is comfortable during the due diligence process, but will also help the firm develop an open and solid relationship from the very beginning. Thus, the more transparent and candid life science firms are during the due diligence process, and the more willing they are to provide the necessary documents to investors, the smoother the due diligence process will be for both the life science firm and the investor.