Archive | August, 2017

Next Phase Interview: NCI Program Director Todd Haim Explains How RESI Boston Became A Showcase For NIH SBIR Grantees

24 Aug

For the third year in a row, the NIH has sponsored a group of grantees to be part of the RESI Boston Innovation Challenge. This week, Dennis Ford(DF) interviews Program Director Todd Haim(TH) to explore how this relationship benefits the NIH’s grantees, and how RESI stands out as a venue for these companies to present.

Dennis Ford
Founder & CEO, Life Science Nation; Creator of RESI Conference Series

Todd Haim
SBIR Program Director, National Cancer Institute

 

 

 

 

 

 

DF: What is the basic reason NIH is showcasing technology at RESI?

TH: The NIH is supporting the SBIR awardees to showcase their own technologies, and we do this at a variety of industry conferences. And the real goal from the NIH´s perspective is that we realize that we cannot support these companies forever; and that each individual company, in order to reach the patient and the market, will need a lot more funding than can be provided just through SBIR. They will need downstream partners and funders, and it is in our interest to help as much as we can to facilitate those partnerships.  RESI along with other early stage investor conferences provides a forum for our portfolio companies to interact with these parties. The conference hosts a unique set of investors and partners that are a good match for our Investor Initiatives program. This is the third year that we will be sending our companies to RESI.

DF: How many NIH-funded companies apply for the RESI Innovation Challenge and how many are selected as finalists?

TH: Over the past 3 years, over 150 companies have applied, and 60 of those have been featured as finalists. 20 at each conference.

DF: What are some key differences you see in the RESI conference compared to other conferences you attend?

TH: I would say two things stand out about RESI. One is the inclusion of Family Offices and groups that you don´t see at many other industry forums and showcases. The other benefit of RESI is the broad base in terms of technology types. Many of the other conferences we have participated in are really focused on one technology area, whether it be devices or therapeutics. RESI has individual tracks that represent devices or that represent therapeutics, which really allows us to present a greater variety of our companies there, and I think that broad focus is very helpful at this early stage.

DF: Is this type of showcasing of NIH-funded technology going to continue?

TH: We continually evaluate the outcomes of our companies’ participation in conferences like RESI to ensure the value of such events to our portfolio companies. We recently found out that CellSight Technologies, one of the companies that attended RESI as part of NCI SBIR’s Investor Initiatives, signed an agreement with Boehringer Ingelheim to partner on a clinical study using CellSight’s technology. We hope that participation in NCI SBIR’s Investor Initiatives will result in additional partnerships and investment for our portfolio companies. Should RESI participation continue to prove effective for NCI SBIR’s portfolio companies and our program continue to have sufficient funding for these efforts, we are likely to continue considering participation in RESI.

DF: Typically, we see for the Innovation Challenge participants up to 50% get funded or get involved in partnerships but we haven’t correlated that to SBIR participants specifically (though I know of around a half dozen off the top of my head that have fared quite well by participating in RESI). 

DF: Tell the readers some great stuff that is happening right now in the NIH funding domain:

TH: Sure. NCI and many of the other Institutes participate in both the Omnibus grant funding opportunity, which is available three times a year and the next receipt date is September 5th. About two thirds, if not more, of the funding for the NIH/SBIR program is actually through the Omnibus solicitation, which is an investigator initiated solicitation. You submit the application and you tell us what you’re working on; then it gets peer reviewed and we consider it from there. Then we have some of the Institutes within the Health and Human Services (HHS) including NCI, using a SBIR Contract Solicitation that goes out once a year to fund high-priority areas for each of those Institutes. The solicitation is now available and applications are due by October 20th. You can find the solicitation on NCI SBIR’s website (https://sbir.cancer.gov), as well as on https://sbir.nih.gov. I would definitely encourage all of the readers to look at both of those funding opportunity announcements with upcoming due dates and consider applying. We are here to work with potential applicants and help them understand how the program works, and how an application can be competitive.  So I encourage you to reach out to our office (ncisbir@mail.nih.gov) or to the SBIR Program Officers and Coordinators across the NIH before you apply. If you would like to speak to a Program Officer before you apply, that is definitely something we can arrange and provide guidance. Come and talk to us, we’re always interested in supporting new companies through the SBIR program and new projects.

How RESI Turned a Good Fit Into an Exclusive Collaboration

24 Aug

By Natasha Eldridge, Director of RESI Conference Series, LSN

natasha-wp-newIn the last 4 years, RESI has facilitated thousands of new connections between early stage companies and investors, and we often hear of successful partnerships and allocations that have begun at this hub of communication and dialogue. In this article, we’ll take a look at one example of a great RESI success.

An early stage therapeutics company was one of 30 companies selected to participate in a RESI Innovation Challenge, out of over 100 applicants. Prior to the event the company used the RESI Partnering software to book a meeting with an investor representing the corporate venture capital fund of a major pharma firm that was looking for assets in their field. Although the startup was a little too early in their development process to match the corporate VC’s criteria, the technology was a strong potential fit with the firm’s pipeline. The meeting went well, and the investor therefore connected the startup to the pharma company’s Business Development team. Two years later, with additional validation for the startup’s assets, they closed a significant collaboration deal with the pharma company. This is how it works in the early stage arena – by using venues like RESI to make your first early connections with major players, you can build bridges to future deals.

This startup was based in a city that’s not established as a major biotech startup hub. It’s an example of how LSN brings together buyers and sellers from all over North America, and indeed the world. Everybody is familiar with the obvious biotechnology centers like Boston and the Bay Area, but many players overlook less obvious sources of new technology. LSN not only marks these other hubs on our map, but we also develop relationships with startups in these areas via our outreach and our “Fundraising Bootcamp” educational workshops which help scientist entrepreneurs understand the details of partnering and fundraising. At the same time, the LSN Research team speaks to investment firms and large pharmaceutical companies worldwide about what kind of technology they need to see.

In this case, the LSN Research Team and Business Development Team were speaking with both the startup and the major pharma firm. Based on the relationships developed both decided to go to RESI and met through the partnering system which matched up their profiles as good fits to meet each other. That’s how we’ve seen RESI lead to so many deals over the last 4 years.

Biotech Family Offices Discuss Direct Investment at RESI Boston

24 Aug

By Lucy Parkinson, Director of Research, LSN

RESI Partnering is now open, providing attendees with the opportunity to book one on one meetings with investors.  If you log in to Partnering, you will see a wide variety of investors available to reach out to, including venture capital firms, big pharma, angels – and family offices.

RESI Boston’s Biotech Family Office sesssion features family office investors from around the world who are making direct investments into early stage drug development companies.  These firms have a variety of strategies, interests and motivations.  If you’d like to know how family office investors think about early stage drugs and what kind of technology catches their eye, this is the panel for you.

Moderated by Colin Widen (CEO, Boston Innovation Capital), the panelists are:

  • Christine Bunt (Venture Partner, 20/20 HealthCare Partners)
  • Pini Orbach (Head of Pharma, Arkin Bioventures)
  • Alex Pickett (Principal, Mediqventures)
  • Jayson Rieger (SVP of Business Development & Portfolio Management, PBM Capital)

We’ve extended the RESI discounted registration until Friday, so if you want to hear from these Biotech Family Offices now is the time to get registered.

Hot Investor Mandate 1: Family Office Invests Early in Novel Therapeutics, Devices and Life Science Tools

24 Aug

A family office based in California invests in primarily early-stage (seed, Series A) companies with truly innovative technologies with a typical investment size of $2-5M per company and can invest as low as $500K. The firm will generally lead investments, and invests globally with no geographic preference.

The firm is seeking innovative technology that is outside traditional biotech. The company is agnostic across life science sectors, including therapeutics, devices, and tools, but will not look at Healthcare IT or digital health technologies. They are interested in therapeutics targeting novel first-in-class targets, and not in biosimilars or repurposed drugs. The firm focuses on early stage preclinical to clinical-stage technology, though may be open to commercial-stage technology depending on the opportunity.

The firm is seeking companies with founders who have big ambitions, and a demonstrated ability to sell their team, investors, and partners on their vision. Previous startup experience is a big plus, but not required, and they will invest in young and first-time entrepreneurs.

If you are interested in more information about this investor and other investors tracked by LSN, please email mandates@lifesciencenation.com

Hot Investor Mandate 2: Major Biotech Firm Looks Externally for Neurology and Rare Disease Assets

24 Aug

A large biotechnology company headquartered in the USA is continuously looking to expand its pipeline through external partnerships and is open to many types of collaboration, including e.g. collaborative research, equity investments, licensing, or M&A. The company considers opportunities from around the globe.

The firm is currently focused on neurodegenerative diseases, neuromuscular disorders, pain, neuroimmunology/-inflammation, other rare neurological diseases, and adjacencies to neurology such as ophthalmology; and other rare and orphan diseases. The firm is seeking platform technologies (e.g. gene therapy/editing) as well as single therapeutic assets that facilitate the identification and validation of new therapeutic targets, biomarkers and patient segmentation strategies. The firm considers projects from post-lead identification and pre-IND to late clinical stages, with an increased interest in Phase Ib and later projects.

Along this line, the company is also interested in diagnostic tools to utilize biomarkers of interest early in clinical trials. The firm is modality agnostic with respect to therapeutic approaches. The firm evaluates deal opportunities on a case-by-case basis, considering a wide range of opportunities from early academic partnerships to M&A.

The firm principally evaluates opportunities based on three key criteria: transformative (‘moonshot’) solution to unmet medical need, sound scientific basis, and clear clinical development and regulatory pathways.

If you are interested in more information about this investor and other investors tracked by LSN, please email mandates@lifesciencenation.com

Hot Investor Mandate 3: Global Venture Firm Invests New $400 Million Fund in Novel Therapeutics and Commercial-Stage Medtech

24 Aug

A venture capital firm with offices worldwide closed a new fund in 2017. The firm predominantly focuses on seed and series A and B investments in early stage biotechnology companies, as well as growth equity investments in medical devices companies. The firm’s typical investment size for early stage companies is $5M-$15M and the firm can allocate up to $35-40M total over the life of an investment. The firm focuses on companies that are based in the U.S., Canada and Europe and is actively seeking new investment opportunities.

The firm’s newest fund closed at $400 million, and will invest in 20‐25 biotechnology companies in the U.S., Canada and Europe.

The firm focuses on novel therapeutics and is opportunistic in terms of subsectors and indications. The firm is interested in novel small molecule and biologic therapeutics that address immuno-oncology, orphan/rare or genetic-based diseases, inflammation, infectious diseases and specific viruses, microbiome, and fibrosis and CNS indications. The firm is also interested in regenerative medicine and gene therapy. In medical devices, the firm is generally agnostic to subsector, but is more interested in revenue-generating devices that address cardiovascular, orthopedic, ophthalmic and neurological disorders. Versant prefers devices with proof-of-concept and strong IP.

The firm prefers that a startup company has a strong and experienced management team or technical experts in the relevant technology. The firm generally is flexible with management teams.

If you are interested in more information about this investor and other investors tracked by LSN, please email mandates@lifesciencenation.com

Hot Investor Mandate 4: Crossborder Fund Invests in Pharmaceuticals and Devices, Interested in 505(b) Repurposed Assets

24 Aug

A venture capital and private equity firm based in Shanghai, China manages both US dollar and RMB denominated fund. The firm invests in Series A rounds at $1-2M, though its sweet spot is investing $10-15M in Series B/C rounds. The firm works closely with local provincial Chinese governments, allowing them the ability to bring technology successfully into the Chinese market. The firm will generally not invest in the seed stage, and seeks opportunities globally.

The firm invests in pharmaceuticals and Class II medical devices, including an interest in 505(b)(2) repurposed compounds, as well as healthcare-related industries. The firm is interested in all therapeutic areas and in early to mid development stage companies. The firm focuses on unmet medical needs with a China market potential.

The firm does not have management team requirements. The firm will typically take a board seat post-investment, and has the capability to lead and co-invest.

If you are interested in more information about this investor and other investors tracked by LSN, please email mandates@lifesciencenation.com