Going For It – The Startup’s Story

By Dennis Ford, Founder & CEO, Life Science Nation; Creator of RESI Conference Series

As I stated in a previous installment, the story is the be-all-end-all in the life of an entrepreneur. Here is the challenge for the folks developing the story: It has to be good enough, and bulletproof enough, that the story on its own can make an impact. Of course, the person who delivers the story will never be truly separate from the story, as the teller is part of the storytelling dynamic…it just doesn’t work that way. However, I do believe that once you get the story crisp enough that anyone in the company can give a lucid and cogent version of THE STORY, the message will be heard.

The past articles in this series we can covered how an entrepreneur has to be up and running from the get-go. You must be ready to take on all comers in the journey of getting your company launched. Predictably, you’re in for the fight of your life, so you better be ready to defend yourself. This also means going on the offensive and attacking, too. Please notice the words we are using here are not fluffy, namby-pamby, kind of, sort of, maybe words. On the contrary, these words are solid, committed and meaningful. I’ll take my idea, my passion, my invention and dedicate my life to it and go for it. Just do it. I’ll fight for it. So this is the crux of the matter: What does “go for it” mean to you? Is your idea of going for it and my idea of going for it the same? Maybe it is, and maybe it isn’t. Read on and hopefully I can help you answer that question. Are you in? Will you fight for it? Or, are you out?

My idea of going for it means putting it all on the line. Commit. Do what you have to do, no matter what. Sell your house? Take out a loan? Get some extra credit cards. Beg for cash from friends and family. All the aforementioned is just the ante into the game; playing the game involves pain, suffering, anxiety, stress, self-doubt, but it is the most exhilarating and empowering time of your life: the ultimate adventure, the stuff your dreams are made of…do this entrepreneurial thing right and become unequivocally empowered. It’s how you feel about being on the edge of the important fundamental aspects of your life. Welcome to the Entrepreneur Elucidated, in all its glory – the good, the bad, and the in-between. I dare say after reading this, a fair number of entrepreneurs may just decide to hang it all up and go back to the safety and security of a stable and meaningful life…please do, as this ain’t gonna be all that much fun, but what true adventure is? It’s always the journey, right?

If you choose to strap in and go for it, the first monster you will encounter in your perilous journey of starting a company is time. Time is not your friend, and time keeps ticking by; it cannot be wasted and will never be recovered. Time owns you, your employees and your company from the get-go. Waste time and you are dead. Adjusting your being around the monster of time is a pivot every entrepreneur has to make internally; they need to start living by the time monster’s clock.

The importance of timing to entrepreneur can be compared to surfing and catching a wave (a market for your product and company). You cannot sit on the sand and catch a wave. You need to learn how to swim and paddle up to the wave and maneuver you and your board through the moving waters. You need to paddle to catch it and then you need to stand up and ride it. Then you need to learn all the tricks of riding the wave to become an adroit surfer. Pick your metaphor and pick your sport…but timing engulfs every nuance and subtlety.

There is the other monster that is always lurking about ready to pounce and that is the Money Monster. So welcome to your two new best friends. Two monsters who will live night and day with you…time and money. No one starts, launches, or grows a company without spending lots of time and capital. No one.

RESI Philadelphia 2019 Innovation Challenge – Check Out the Winners

By Karen Deyo, Investor Research Analyst, LSN

This past Monday, June 3rd, 35 companies representing 9 countries competed in the RESI Innovation Challenge. These companies showcased their exciting technologies, from therapeutics to diagnostics, medical devices to digital health. Taking place at the Convene Cityview in Philadelphia, RESI attendees ‘invested’ their RESI Cash in their favorite companies. We congratulate all finalists selected to participate, and we are delighted to announce the winners – the three companies that received the most RESI Cash. Check them out below!

First Place: Soundable Health Inc

Soundable Health is a digital health company with leading sound AI technology. Our mission is to help people to understand and manage their health and diseases easily to live with dignity. Our first product, PRIVY™, is a mobile app that records the sound of the urine stream on the smartphone at the bathroom and turns it into clinical-grade urine flow exam results for prostate and bladder patients and their physicians. Through alpha and beta test we launched the open-beta app in the US and Korea and have collected over 4000 actual measurement data and results from users and physicians. Especially, over 100 physicians we met in Korea and in the US notice the possibility of the platform for greatly improving clinical workflow and care process. Including Massachusetts General Hospital, Texas Children’s Hospital and Seoul National University Hospital, 6 clinics/hospitals have been participating in clinical researches since 2017. Also, health insurance companies and pharma companies are very much interested in the world’s first & largest real-world data in urology. We’re planning to start unpaid pilots in private practices and institutional settings from June and aim to expand partners for paid pilots with initial revenue by early 2020.

Catherine J Song, Founder & CEO, Soundable Health

 

Second Place: Drusolv Therapeutics

Drusolv Therapeutics is a clinical-stage drug company based in Philadelphia. We are developing a novel, high-dose statin for early intervention in a blinding eye disease called age-related macular degeneration (AMD). AMD is the leading cause of blindness in developed countries, affecting more people than glaucoma and diabetic retinopathy combined. Unfortunately, there are currently no drugs for intervention before the onset of late-stage vision loss. This is a $4B per year, completely unmet need. Our product, Ocustatin™, was developed at Harvard University. A very successful proof-of-concept clinical trial has shown that early intervention with Ocustatin substantially reduces progression to late-stage blindness. The founder and CEO of Drusolv is a successful serial entrepreneur with extensive experience in AMD.

John Edwards, CEO, Drusolv Therapeutics

 

Third Place: AIBIOS Co Ltd

AIBIOS, CO., Ltd. is a private pharmaceutical company and specializes in the development of novel small molecule drugs for inflammation related diseases. AIBIOS’s mission is to develop novel drugs modulating immune responses to satisfy highly unmet medical needs. AIBIOS is developing an oral drug for inflammatory bowel disease (IBD). The drug candidate, AIB301, has a novel mechanism of action exerting biological effects in modulating immune responses in intestinal mucus, not only the adaptive immune system but also the innate immune system, which distinguish itself from other drugs and drug candidates for IBD treatment. AIB301 is in IND enabling stage with GMP grade drug substance will be delivered in June 2019 and soon will be evaluated with GLP toxicity preclinical studies.

Chao Pin Lee, Chief Operating Officer, AiBIOS
Akio Sato, CEO, AIBIOS

RESI Philadelphia: Check Out the Program Guide Now

By Dennis Ford, Founder & CEO, Life Science Nation; Creator of RESI Conference Series

The next Redefining Early Stage Investments (RESI) conference is right around the corner, and we are excited to release the digital program guide in anticipation of the event! The RESI conference was created to bring early-stage companies together with early stage investors and strategic channel partners. The theme is to maximize the capability of ­finding partners who are a ­fit for the stage of development and product of a fi­rm. With attendance close to venue capacity and meetings slots filling up, there are many opportunities to make successful connections, for investors, channel partners and startups.

Seeking funding for life science companies comes with multiple challenges. First, there is an abundance of early-stage companies seeking capital in the US and globally, as a result of immense governmental R&D support at life science technology hubs around the world. These companies, whether university spin-outs or independently founded, ­find themselves competing for a limited amount of regional capital, and many of them require strategic advice to help launch and stage a successful global fundraising campaign.

Second, it can be extremely dif­ficult to ­find and get in front of the active investors in the space, be they angels, family of­fices, VCs, PE, or Pharma. This is often due to the sheer volume of deal opportunities in their inbox, making it hard for the startup to differentiate itself. Compounding the early stage funding dynamic is the lack of a public face for many family of­fices, most choosing to be in stealth mode under the radar screen, posing yet another challenge to getting in front of the right investor.

What’s unique about RESI is that the event is cross border and cross domain. RESI focuses squarely on connecting startups with 10 categories of global investors across the silos of Drugs, Devices, Diagnostics and Digital Health, the “4 Ds”. RESI caters to both the earliest stage startups, those seeking grants, seed and angel capital, and the early stage firms who seek series A and B funding. Because LSN organizes a RESI conference every few months, fundraising CEOs and investment partners can incorporate RESI into their monthly global business activities.

Take a look at the RESI Philadelphia program guide to see the content scheduled, including an amazing line up of panelists, as well as the exciting companies participating in the Innovation Challenge and Innovators’ Pitch Challenge. See you next week!

LSN-KOTRA Partnership: Introducing Promising Technologies from South Korea

By Claire Jeong, Director of Research, Asia BD, LSN

claireOur next Redefining Early Stage Investments (RESI) Conference in Philadelphia is now just 4 days away, and is anticipated to be our largest RESI held concurrent with the BIO International Convention. A few weeks ago, I covered LSN’s partnership with the Korea Trade-Investment Promotion Agency (KOTRA) and supporting organizations to bring a large delegation of startup companies from South Korea, similar to what we have done at last year’s RESI around BIO. We believe that all 10 participating companies have strong potential to scale and are fully capable of engaging with global investors and strategic partners. Some of these companies were selected to participate in the RESI Innovation Challenge and will be exhibiting posterboards of their technology throughout the entire day, and select others will be presenting short company pitches to a panel of active life science industry professionals during the “Korea Pitch Challenge” session from 11:00 – 11:50 am. We hope you will have the chance to meet some of these companies at RESI next week!

Participating Companies:

Orum Therapeutics (OT)

Orum Therapeutics (OT) is a biotech company with offices in Daejeon, Korea and Cambridge, Massachusetts. OT developed cell-penetrating antibodies that can access the cytosol of living cells following receptor-mediated endocytosis. This will enable producing next-generation therapeutic antibodies that directly target cytosolic proteins, which are associated with many untreatable or difficult-to-treat human diseases including cancer and other rare diseases. OT can engineer various therapeutic antibodies capable of entering the cytosol. Because OT’s fully human antibodies do not require chemical conjugation or formulation for delivery, their manufacturing procedures are similar to those used for any therapeutic monoclonal antibody. OT’s antibodies can be engineered to specifically bind different cell-surface receptors to enhance targeting to specific tissues.

NEXEL

NEXEL focuses on biotherapeutic development where candidates are derived from internal stem cell-based research. Using its expertise in stem cell, NEXEL also provides highly pure and functional iPSC-derived cell products. NP-011, a pre-clinical stage anti-fibrotic recombinant protein, has a potent anti-fibrotic activity. It has demonstrated its efficacy in NASH, IPF, MI animal models and has demonstrated an excellent safety profile in a 4-week multi-tox study. NEXEL offers iPSC-derived cardiomyocytes, neurons, and hepatocytes for drug discovery and development activities.

Genesen Inc.

Genesen Inc. is developing peptide-based new drugs that selectively inhibit toll-like receptors (TLRs), to treat autoimmune diseases. Computational simulation and phage display are used to discover peptide candidates, followed by secondary structure prediction and molecular dynamics simulation to optimize the peptide sequence. The experienced Genesen team is aimed not only to develop the first-in-class peptide drug to cure lupus patients, but also to expand to other immune diseases such as rheumatoid arthritis, IBD, Psoriasis and Multiple sclerosis.

Soundable Health

Soundable Health is a digital health company with leading sound AI technology. Our mission is to help people to understand and manage their health and diseases easily to live with dignity. Our first product, PRIVY™, is a mobile app that records the sound of the urine stream on the smartphone at the bathroom and turns it into clinical-grade urine flow exam results for prostate and bladder patients and their physicians Through alpha and beta test we launched the open-beta app in the US and Korea and have collected over 4000 actual measurement data and results from users and physicians.

Shaperon

Shaperon is a biotech company navigating in the universe of immunology and inflammation. Their flagship compounds are TGR5 agonists, the first of its kind developed for inflammatory diseases such as atopic dermatitis, ulcerative colitis, sepsis, and Alzheimer’s disease. TGR5 receptor as signal transduction modulator is the optimal target for inflammatory diseases where immune homeostasis is critically damaged due to multiple factors and its restoration requires global regulation of immune cell interactions.

Genome Opinion

Genome Opinion‘s goal is to integrate genomic and health data to develop novel technologies to improve human health. The Company was co-founded by a medical doctor from Seoul National University Hospital and researchers from Genome Analytics of Samsung Group in 2017 – together, our team has +30 years’ experience of genomic data analytics. We are currently focusing on integrating NGS based in-vitro diagnostic test results and longitudinal health record data, in order to predict and diagnose risks related to cardiovascular diseases and cancers. The Company launched a study on inherited risk related to cardiovascular diseases by conducting analysis on ~36,000 samples from Korea Biobank. We have also formed a strategic alliance with a health checkup clinic in Korea to conduct cardiovascular disease related risk analysis on ~5,000 personnel.

BIO3S

BIO3S is a research-oriented startup launched in 2016 with its mission to benefit life for humans by uncovering host defense mechanism against virus infections. Based on big data analysis obtained from proteomics, metabolomics, and transcriptomics, BIO3S developed two core bioconversion technologies: (1) producing mannunnorate oligosaccharide from seaweed alginate using safe bacterial enzyme, and (2) developing oncolytic virus using virus culture technology.

Tomocube, Inc.

Tomocube, Inc. is a high-tech startup with optical diffraction tomography and DMD technology. Opening a new era for microscopy, Tomocube’s revolutionary 3D holographic microscopy technique makes it possible to take 3D images of live cells without using fluorescent probes which may cause severe phototoxicity and require time-consuming preparation steps. Its products are actively used in Harvard Medical School, MIT, UPMC, and other leading institutions.

NuriBio

NuriBio has vigorously focused on research and development of PCR-based genetic analysis tools, resulting in proprietary technology that outperforms its’ competitors. NuriBio’s PROMER™ tech is composed of DNA-RNA-DNA structure and performs primer and probe function simultaneously, unlike primer and probe system consisting only of DNA. RNase H enzyme, which degrades the RNA-DNA structure within PROMER, is added and only when the PROMER RNA site binds precisely to the target gene, the RNA-DNA structure is degraded and amplification begins. Therefore, only the target gene can be selectively amplified, so that it is possible to realize high performance with low cost without additional experiments with fewer components.

IH Bio

IH Bio’s cancer immunotherapy (IH002B) is a monoclonal antibody therapy that induces complete remission (CR) in the most advanced metastatic pancreatic ductal adenocarcinoma as well as in a wide range of tumors at much lower concentrations. It has also been reported to induce CR in end-stage cancer. Histologically, the process involves fibrotic encapsulation of the tumor and creation of a space between the normal and cancerous tissues to induce spontaneous tumor resection, thus completely preventing tumor growth, motility, invasion, and metastasis.

Sponsoring Organizations:

Korea Trade-Investment Promotion Agency (KOTRA): KOTRA is a Korean government agency dedicated to promoting international trade and investment, drive the nation’s economic development, and build prosperity for the global community. Through its 129 offices in 84 countries, KOTRA serves small and medium-sized Korean enterprises looking to tap into the overseas markets. Cultivating innovation and building a vibrant, sustainable startup ecosystem is key to reaching the next stage of Korea’s economic growth. To that end, KOTRA is committed in mentoring rising startup companies and providing institutional support to facilitate their continued success.

Korea Biotechnology Industry Organization (KoreaBIO): Korea Biotechnology Industry Organization (KoreaBIO) emerged in 2008 following the merger of three biotechnology industry associations in Korea. Representing over 300 corporate members from the pharmaceutical and biotechnology sectors, KoreaBIO offers training programs and policy advocacy roles to improve the regulatory climate, promote R&D investments, and facilitate global partnerships.

Bluepoint Partners: Bluepoint Partners is a partnership-driven startup accelerator and an early stage VC fund that concentrates on bridging talented high-tech entrepreneurs with real global solutions.  As champions of progressive startups, BP’s partners and expert mentors work hand-in-hand with entrepreneurs enabling them to build a viable business, make connections, raise capital, seek growth, and fulfill their vision.

Korea Institute of Marine Science & Technology Promotion (KIMST): Since 2006, the Korea Institute of Marine Science & Technology Promotion (KIMST) has led the nation’s marine science research and ocean management planning initiatives. KIMST develops and implements national marine policies, establishes ocean planning strategies and systems to maximize productivity, and drives future growth by putting research results to practical use.

Look Who You Can Meet at RESI Philadelphia on Monday

By Lucy Parkinson, VP of Investor Research, LSN

RESI is imminently arriving in Philly, bringing hundreds of life science investors dedicated to early stage investments together in one venue to meet with biotech, medtech, diagnostics and digital health CEOs.  RESI Partnering is still in full swing, with many hundreds of meetings booked and hundreds more still to come.  If you’re looking to meet investors and raise capital, see below for the firms and funds you can connect with at RESI Philadelphia.  We are looking forward to seeing you there in just a few days!

Confirmed RESI Philly Investors

And More…

There’s Only One Choice If You are in Philly on June 3rd

By Gregory Mannix, Vice President International Business Development, LSN

RESI Philadelphia is surpassing our expectations. We have over 300 investors and channel partners signed up, which continues our run of having a 1:1 ratio of investors to fundraising CEOs.  The ROI of attending RESI and scheduling investor meetings, not to mention the ad-hoc meetings you will have by just being in the venue, is amazing. We estimate that the RESI conference has helped over 300 companies raise over $400 million in funding. The big differentiator of RESI is that we vet all of our investors, and unlike other conferences, we do not classify consultants and investment banks as investors. If you are looking for a Memorial Day discount, reach out to me:

g.mannix@lifesciencenation.com

See you at RESI!

UNPRECEDENTED ACCESS TO INVESTORS

Click to See RESI Agenda

Meet the Innovation Challenge Finalists at RESI Philadelphia on June 3rd

By Claire Jeong, Director of Research, Asia BD, LSN

claireWith Redefining Early Stage Investments (RESI) Philadelphia just 10 days away, we are very excited to announce the top innovative companies who were selected for the Innovation Challenge. This is our third RESI held concurrent with BIO International Convention week, and the competition was among the highest. As a result, we have selected a few more companies to participate! As usual, various sectors including therapeutics, medical devices, diagnostics, and digital health were represented from applicants all over the world. The Top 35 selected companies reflect the global life sciences network of Life Science Nation and RESI, representing 9 different countries, from Asia to the Middle East. For these companies, the Innovation Challenge presents as another opportunity to showcase their technologies outside of the one-on-one partnering sessions that will be held all day at the partnering forum.

If you will be attending our upcoming RESI, please take the time to visit our exhibition hall at the 14th floor of Convene Cityview to learn more about these promising technologies. All attendees will be provided with “RESI Cash” which will allow them to “invest” in the companies of their choice. If you are interested in attending but have not yet registered, it is still not too late.

For those who are interested in applying for our next Innovation Challenge, please note that we will be organizing RESI Boston on September 11th. For now, we look forward to seeing everyone in Philadelphia. Congratulations to the selected Innovators!

Therapeutics

Digital Health

Diagnostics

Medtech Devices