Beyond the Pitch: Why Life Science Startups Fail and How BD Assist Closes the Execution Gap

29 Jul

A deeper dive into what really moves the needle for early-stage fundraising

By Dennis Ford, Founder & CEO, Life Science Nation (LSN)

DF-News-09142022A few weeks ago, we introduced BD Assist, Life Science Nation’s full-service global partnering campaign designed to take the burden of business development off the founder’s desk and get real investor meetings on the calendar. The response from experienced founders was immediate.

Here is the truth: BD Assist is not for first-time founders who are still learning the ropes. It is built for the second, third, or fourth time scientist-entrepreneur. The one who already knows how hard this game is, who is tired of chasing down investor meetings between running a company, and who understands the real value of having a professional team help run the global campaign infrastructure.

If you missed the original rollout, you can view the BD Assist overview deck here for a clear breakdown of how the system works.

Why Execution Still Kills Good Science
Even with scientific momentum and breakthrough data, more than 90 percent of early-stage life science companies still fail. Not because the science is not good, but because most founders never make it through the long middle: the grind of targeting, messaging, outreach, and follow-up. They do not reach enough of the right capital investors and licensing partners. They do not have a CRM that tracks investor touchpoints. They do not have time to build and run a campaign while also managing a preclinical program or preparing for the next financing round.

BD Assist exists to fill that gap. To build the campaign, manage the outreach, and hand the founder a pipeline of matched meetings so they can do what they do best. Show up, pitch hard, and close deals.

What BD Assist Actually Does
At its core, BD Assist is a global investor and partner matching engine, backed by a professional services team that handles the heavy lifting. It is not just coaching or strategy. It is a full campaign execution.

  • Matching 600 to 800 capital investors and licensing partners based on stage, product, and deal profile
  • Direct introductions, meeting scheduling, and post-meeting follow-up across LSN’s global network and the RESI conference series
  • CRM setup and outreach execution so you can track progress, engagement, and pipeline movement
  • Messaging and content coaching to sharpen your story across decks, summaries, and calls
  • Strategic support from executive coaches who have helped close hundreds of investor and licensing deals

Need to See the System
Watch our Investor Database demo to understand how we match based on fit, not just category.
Take our free campaign readiness assessment to see if you are ready to scale your outreach.
Or sign up for the next RESI Conference to meet matched investors and pitch in the Innovator’s Pitch Challenge.

This BD Assist Model Works
Our partnership with the Brisbane Economic Development Agency proved it. Over the course of two years, 90% of companies raised more than $ 110 million. Why? Because we did not just teach them how to pitch. We provided them with a comprehensive global campaign system and assisted in its implementation. Click here to read the case study article.

Who is BD Assist Really For
BD Assist is for scientist-entrepreneurs who are already in motion. Founders who have been through a raise know how time-consuming investor engagement really is and are ready to hand off the execution to a trusted team.

Your job is to show up to meetings and move the needle. Our job is to fill the calendar with the right meetings, every week, for the next 9 to 18 months.

Want to Get Started
Contact resi@lifesciencenation.com to learn more.

Because in life sciences, science gets you noticed. Execution gets you funded.

Why Impactful Storytelling Isn’t Optional in Life Sciences

29 Jul

By Tinotenda Chanakira, CEO of Revnuu | Life Sciences Commercialization Strategist (Special Guest Contributor)

In the life sciences, great science isn’t enough to make it out of the lab. Across biotech, medtech, and diagnostics, many teams are advancing transformative healthcare innovations—but still struggle to secure the funding, partnerships, or clinical traction they need. The culprit is rarely bad research, data or scientific innovation. More often, it’s an unclear or underdeveloped narrative.

Too often, life sciences companies present their breakthroughs in ways that prioritize technical complexity over clarity and resonance —visually and orally. Their decks are filled with mechanism-of-action diagrams, regulatory timelines, and patent claims—but little about real-world human impact. Meanwhile, capital markets are tightening, partner deal cycles are lengthening, and competition for attention has never been fiercer. In this environment, storytelling isn’t a marketing tactic. It’s a core business competency.

The challenge is that life sciences companies must communicate across very different audiences. Technical stakeholders—Key Opinion Leaders (KOLs), regulators, clinical advisors—require precision and depth. Commercial stakeholders—investors, distributors, potential acquirers—want proof of market potential and differentiation. And at the center of it all, patients and physicians seek hope, clarity, and relevance.

When a company’s narrative fractures across these touchpoints, the result is confusion, inconsistency, and distrust. Alignment stalls. Partnerships hesitate. Capital walks. To avoid this, founders and leadership teams must develop a coherent, multi-layered story that is not only technically sound but also emotionally and strategically compelling.

Over time, I’ve found that the most successful companies tend to master four core narratives. While the terms themselves have been shaped by broader industry dialogue—especially the work of Life Science Nation—this is how I’ve seen them come to life across real-world negotiations and commercialization journeys.

1. The Founder’s Core Motivation

Investors fund conviction as much as they fund IP. A founder’s story becomes the emotional and philosophical backbone of the venture. In life sciences, this often stems from a moment of deep personal or clinical proximity to the problem—a diagnostic delay, a therapeutic failure, or the loss of someone close.

The most resonant founder narratives don’t just showcase academic credentials. They surface the “why” behind the work. One oncology startup I advised pivoted its entire strategy when the founder lost a parent to late-stage metastasis. That story reshaped how partners viewed the company—not just as a platform, but as a mission-driven force.

2. From Lab to Life-Changing Impact

In science-based ventures, it’s easy to over-index on technical novelty. But partners don’t invest in “clever.” They invest in outcomes. The core question your technology story must answer is: What becomes possible now that wasn’t before?

In life sciences, this means anchoring your innovation in patient outcomes—not just mechanisms. “Our CRISPR-edited CAR-T therapy reduces relapse rates by 47% in refractory ALL” communicates far more than “novel lipid nanoparticle delivery system.” Precision and proof points win here. In fact, 83% of business development executives cite “clear patient impact language” as the single most missing element in pitch materials (LSN Survey, 2024).

3. When Treatment Becomes Transformation
Human outcomes are more compelling than preclinical data—always. This story focuses on transformation: how lives change because of what your product enables. Whether it’s earlier diagnosis, improved quality of life, or reduced healthcare burden, this is where the emotional gravity sits.

But emotion alone isn’t enough. The most effective patient stories also tie into economic logic. For example: “Maria’s Stage I diagnosis saved $218,000 in late-stage care costs.” That intersection of human and system-level impact is what resonates with both payers and partners.

4. From Validation to Velocity
Finally, partners want to see signals of commercial discipline. This doesn’t mean focusing solely on how much funding you’ve raised. Instead, highlight validation milestones that reduce perceived risk—real-world pilots, clinical endpoints, regulatory wins.

“CE Mark secured with 94% sensitivity in a real-world cohort” tells a far more powerful story than “Closed $20M Series B.” The emphasis should always be on de-risking through traction—not just hype.

These four stories don’t live in a pitch deck—they live across your organization. They must be practiced, refined, and embedded from leadership through to field teams. When aligned, they help companies accelerate partnership timelines, deepen investor conviction, and drive internal cohesion across functions.

If you’re unsure whether your narratives are aligned, ask yourself:

  • Can our team clearly articulate the founder’s “why” without defaulting to credentials?
  • Do our technology explanations compel clinicians to lean in?
  • Do our patient stories move decision-makers beyond the data?
  • Do our commercial milestones give partners confidence in our go-to-market plan?

If the answer to any of these is “no,” then it’s time to sharpen the story. Because in this industry, the science must speak—but the story must win.

About the Author
Tinotenda Chanakira is the founder and CEO of Revnuu, a commercialization strategy firm serving deep tech and life sciences ventures globally. With over 50 clients supported across Europe, North America, and the EMEA regions, Revnuu helps founders turn scientific breakthroughs into scalable, market-ready impact. The firm operates between Barcelona and Basel, guiding companies through the real-world complexities of product, capital, and growth.

Pullan’s Pieces #3 – January – A Corner on Market Sentiments – Seed to Series A

29 Jul

As the saying goes, “What’s in a name? That which we call a Series A by any other name would smell as sweet.” Er… something like that, right? Hmmm, maybe it went a little bit differently.

But whatever it be, or not to be😊, the Seed Round is the new Series A. Clearly. I think we’ve all felt it for sometime but the data is in and the good ‘ole Series A just don’t buy what it used to. Nahhh… the Seed round does that, and it may buy more (equity) than it used to as a Series A (more data hunting and crunching required but one gets a sense that the venture capitalists are, well, capitalizing).

Labiotech does a really nice job collecting and summarizing a variety of topics related to financings and dealmaking in the biotech sector and the 2024 breakdown of funding offers the following approximations (roughly, with some rounding made by this author):

The internal breakdowns for amounts invested look like this:


Readers of this corner will know that we keep a close eye on the XBI

As usual, the outliers can skew the numbers (more on this in a moment) but the median amounts invested into these rounds puh-rihhhty much drive the nail in the coffin of the old thinking about Series dynamics. This data could be charted in another way in which an inverted bell curve would appear and a GAPING hole between $20M and $50M would stare back at you. Think about that for a moment… if you can’t get to value inflection for ~$15-20M, you better be raising $60-75M and have multiple reasons to do so as a cursory view of the companies listed in the dataset further indicates that the lower outliers (sub-median) on the Series A were generally geared for “finding out” about a single asset in the clinic.

Back to that previously mentioned outlier that can skew the averages… it also happens to bring even more of a spotlight to those famed words from Shakespeare which began this Corner on Market Sentiments. One of the companies in the 2024 data set raised a whopping $100,000,000 … as a Seed Round!! Indeed, a rose by any other name…

Hot Investor Mandate: VC Firm Headquartered in Asia Makes Early- to Expansion-Stage Investments Into Digital Healthcare Companies With Asia Market Potential 

29 Jul

A venture capital investor based in Asia with a presence in the US makes early- to expansion-stage investments across multiple sectors, ranging from smart cities and fintech to healthcare. Investment size is highly variable depending on the company’s stage. The firm invests alongside other venture capital firms in companies located in North America and Europe that have a market expansion strategy into Asia. 

The firm takes an opportunistic approach to digital healthcare companies, particularly those leveraging AI and bioinformatics to accelerate the drug discovery process. 

The firm seeks entrepreneurs who are passionate, driven, and enthusiastic, with sustainable business models and globally scalable ideas. 

If you are interested in more information about this investor and other investors tracked by LSN, please email salescore@lifesciencenation.com

Hot Investor Mandate: Venture Arm of Investment Bank Seek Therapeutics and Medtech Companies in CNS, Oncology, and More, Focusing on US Based Opportunities

29 Jul

An investment bank headquartered in the US  does not act as a traditional investment bank, as the firm participates in venture capital, investing in and working with early-stage technology and life science companies with the main goal of taking the companies to public markets. The firm has also spun out and out-licensed technologies from universities and has capabilities to help with company formation, business strategy, IP, and early IPOs. The firm utilizes a sister company to further analyze company technologies and IPs. The firm can fund from $5-12M USD from Seed to Series A rounds with preference in US-based companies, though the firm is open to global companies. 
 
The firm is looking at biotech, medical devices, and diagnostics companies and is technology-agnostic. The firm generally does not look at digital health. There has been strong interest in immuno-oncology, neurology, and CNS. 
 

The firm works closely with companies and founders and will lead investment rounds. The firm typically requires taking a board or observer seat while deciding strategy, and once the company goes public, the firm will bring in a board member with expertise in the field. 

If you are interested in more information about this investor and other investors tracked by LSN, please email salescore@lifesciencenation.com

Hot Investor Mandate: VC Firm Focuses on Global Early-Stage Medical Device Investments, With Strong Interest in Companies Developing Class III Devices

29 Jul

A venture capital firm, founded in 2019, is a global venture capital investor. The firm specializes in early-stage medical device companies and actively leverages expertise and industry resources to support portfolio companies. The firm prefers taking a leading role in investment rounds and may seek board seats in such cases. 

The firm focuses on medical devices and is open to all subsectors and indications. The firm seeks innovative technologies, primarily investing in Class III devices, and occasionally considers Class II devices if they demonstrate significant innovation. The firm is open to working with companies at all stages, including those in the early idea phase. 

The firm prefers founding teams with strong scientific expertise and comprehensive knowledge of their respective fields. 

If you are interested in more information about this investor and other investors tracked by LSN, please email salescore@lifesciencenation.com

Hot Investor Mandate: USA-Based Early-Stage Venture Fund Invests in Seed Stage Companies With Opportunistic Interests Across Life Sciences

29 Jul

An early-stage venture capital firm, headquartered in the U.S., allocates roughly 40% of its investments to life sciences. The firm primarily invests from the Seed stage, with the ability to provide follow-on capital. Check sizes are flexible, typically reaching up to mid-6 figures. The firm is open to evaluating opportunities from global companies. 

The firm has broad interests in life sciences and healthcare sectors and considers all types of innovative technologies and indication/disease areas.  
 
The firm does not impose specific requirements on company structure or management teams. 

If you are interested in more information about this investor and other investors tracked by LSN, please email salescore@lifesciencenation.com