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Marketing Your Life Sciences Firm: A Primer

4 Dec

By Dennis Ford, Founder & CEO, Life Science Nation, November 2012

The primary marketing challenge for the life science CEO is finding the sales and marketing expertise required to realize capital inflows. Compounding this issue is the fact that the SEC and FINRA regulatory landscape is morphing at a time when institutional life science investors are re-evaluating investment strategies and reshuffling portfolios. These dynamics require life science executives to review and recalibrate their sales and marketing strategies.

In order to do this life science executives need to answer three main questions:

  • What is the current fundraising environment?
  • How are firms raising capital and building their investor base?
  • What must firms do to prepare and execute successful fundraising campaigns?

Fundraising is not a singular event. In fact, it must be an integral and ongoing part of every firm’s business strategy to validate a firm’s model, and to ensure profitability and growth. Although fundraising at most firms tends to ebb and flow, it should never be far from your collective consciousness.

Thousands of life science executives are currently seeking allocations and yet many don’t understand what it takes to execute a sales and marketing campaign. These executives need to realize that effective sales and marketing is key to raising capital from life science investors, and that effective implementation requires years of experience.

The Fundraising Environment

Back in the days of yore, investors could discover a high-flying life science firm. If the firm had the right business plan and a compelling story, investors would make an allocation. The whole due diligence process was often completed in a relatively small amount of time, typically six to twelve months. This was more on the passive side of fundraising. An interested VC would herd together other co-investors and though the fund raising staff had to be nimble and responsive, the money was still there.

Active fundraising didn’t require much more effort. Times were good. When life science firms wanted to raise capital, they could call upon their stable of investors and ask them to increase their commitments.

Those days are long gone. The paradigm has shifted. No longer are investors coming in over the transom, and the financial crisis caused many stalwart, dependable investors to leave firms. Today, life science companies looking to raise capital must “go outbound” and find investors that are a good fit for their products.

Unfortunately, this change comes at a time when raising capital is more urgent than ever. Most firms, regardless of their place in the market, face the same problem: their funds have dwindled to record lows. The economic downturn caused many investors to stop investing all together.

Transition Creates Opportunity

Although life science executives are scrambling to replace assets and find new investors, they are not the only group in transition. Alternative institutional investors are also undergoing a huge change. They are rethinking past strategies and reshuffling their portfolios. VC and PE firms are being forced to realize that they have not been successful in turning investments into returns and have lost a lot of money. The VC community – with the exception of some marquee names – has been severely hindered and may or may not re-emerge.

This dynamic has created some problems, but more importantly, it has created opportunities. New categories of investors are open to talking with life science executives that they declined to speak with in the past. Investors are also examining strategies that previously were not on their radar screens. Indeed, family offices are filling in some of the gaps by investing directly and there is a trend in the market to find the new VC.

At the same time, investors are echoing the same message to life science executives. You must scrutinize your projections, show a good track record of adroit development and discovery capability, educate and engage us in dialogue, and let us vet the executive team. Only then will we seriously consider your firm.

Times have changed.

Although much money is still on the sidelines, investor data shows that allocation distribution is trending upward. A recent report published by Silicon Valley Bank found that venture-backed M&A is on the rise, and that big exits (deals greater than $50 million in equity) are at a seven year high at $12.5B[1]. The average upfront deal size for life sciences firms has also increased[2], and both of these factors have led to increased investor interest in life sciences sector.

So how do life science firms go about raising capital and growing their investor stable in this new environment?

Think Differently, You Have No Choice

Going outbound is the new modus operandi. However, outbound marketing and sales are their own distinct universe. If you do not know this, believe it to be true.

Outbound marketing and inbound marketing couldn’t be more different. It is safe to say the two are like night and day. It would require an additional white paper to describe all the subtle differences between the two, but here is a concise snapshot – a fundraising staff comprised of marketers that simply screen incoming VC calls and identify those of value are not the right people to make the hundreds of outbound calls per week that are necessary in this environment.

Inbound marketers are not familiar with the incredible effort it takes to vet a target list of investors. They don’t know how to speak with a cold prospect. They are not used to making 10 to 15 calls and receiving only one back. And they don’t know how to set up conference calls and road trips with prospects.

When the economic world changed, so did the job descriptions of the fund raising and marketing staff. Inbound and outbound are two distinct marketing styles. Each attracts certain personalities and requires special talents. It is imperative to adjust to the new paradigm if your firm is going to successfully raise capital.

First Things First

If you are considering launching a fundraising campaign—or are in the throes of one—how you go about it will determine your success. One of the most important facets to grasp is that sales and marketing take money, time, and commitment.

The first major hurdle many life science firms must overcome is accepting the old adage, “it takes money to make money.” Every life science firm needs to budget the dollars necessary to prepare a fundraising campaign.

The second obstacle is that raising capital today takes a minimum of six to eighteen months[3]. Life science firms must come to grips with the fact that investors want to observe a firm’s development milestones for several quarters and establish not only a compelling dialogue but also a relationship with a firm’s major players.

The third hurdle is that continuous fundraising is a firm-wide commitment. From the top of the organization to the bottom, every employee must buy in. This can happen if you choose an effective fundraising leader—someone who cannot only communicate the importance of this effort up and down the ladder, but also can win everyone’s support.

Many firms have a full-time professional who heads fundraising or marketing and can lead this effort. However, as noted earlier, this is usually not the same person that led your inbound marketing efforts during better times.

If your firm is not big enough to afford a full-time marketer or a fund-raising life sciences firm, then one of the partners must fill this role. How do you determine who is the best candidate to represent the firm to potential investors? Ask this question: which partner can best explain who we are and what we do in a cogent, lucid, earnest, and succinct way?

After you have designated a leader, he or she must assemble a team. A marketing team is like any other team; each player is assigned a position and is expected to know the playbook and execute. It takes teamwork to win. In the new outbound sales and marketing model, the team often includes outsourced firms.

The bottom line is that someone has to take responsibility for raising capital, and the rest of the firm must fall in line and support the effort.

The Value of Keeping Your Investor Data Current

The first task the marketing team must tackle is to decide which investors to target. At the top of the list should be the investor categories with which the firm has been successful in the past. For example, if foundations and endowments have been the firm’s sweet spot, determine if they are still viable prospects.

The team must then ask if there are additional investor categories to consider. Perhaps now is the time to seek a new type of investor such as family offices or hedge funds.

After the team has agreed on one or more categories to target, the next task is assembling a target list.

The first place to look is in-house. In-house investor lists are typically an amalgamation of spreadsheets, Microsoft Word documents, e-mails, and other disparate files and databases. They are a mix of personal and company contacts. They may even include some third-party lists bought haphazardly over the years. Usually, all these lists have been gathered but not maintained by the in-house marketing staff.

Many marketers incorrectly assume that these lists can be the basis for a fundraising campaign. In fact, nothing creates outdated lists faster than market churn, and there has been a lot of it in the past few years. Considering all the changes in the alternative industry caused by the financial crisis, this data must be viewed as circumspect.

Some marketers may attempt database triage on in-house investor lists, but most quickly abandon the effort, electing to start from scratch and purchase a list. They believe that this will save them time, money, and much frustration, but often the opposite is true.

Most investor databases come in two forms: out of date and very out of date. In fact, it is challenging to find a source that even provides accurate phone numbers, never mind accurately providing the types of life science firms and strategies that investors are seeking. Calling incorrect numbers, reaching the wrong people, and chasing companies that have long gone out of business stymies phone campaigns; large numbers of bounced messages derail e-mail marketing efforts.

Successful fundraising campaigns are those that target investors whose interests match the firm’s product offerings. For that you need current and accurate investor and mandate information.

Thus, the adroit marketer takes a two-pronged approach. First, knowing that there’s probably some gold buried in the in-house data, he or she will vet these lists. Though this can be a gargantuan task and may delay the launch date, the smart marketer understands that it is a necessary step. Secondly, he or she will investigate third- party sources and do the research necessary to find the list and database providers that update their information frequently.

After completing the above steps, the marketer assembles a current database that combines the best targets from in-house sources with a solid third-party list. Starting fresh is a good way to begin a campaign and put into place the processes that are necessary to maintain a current database.

Keep It Simple

After the database is in place, you can begin to formulate plans on how to use the investor profiles. Much of what follows may sound obvious. However, sometimes simple marketing concepts get lost in the hubbub of arranging investor meetings and getting new money in the door.

Typically, it is best to divide the master database into two lists of investor targets. The first contains the low-hanging fruit – the obvious fits, the strategic fits, and those that are similar to targets that marketers have successfully sold to in the past.

The second list is comprised of new investor candidates—prospects that your firm has not approached before. These may be new investors or investor categories that you feel are good fits based on their profiles.

When you have the two lists, choose a method for selecting investors to contact. Location is the best method. Which investors are a walk, car ride, or short plane trip away? This is where you should concentrate your efforts. This may seem an obvious approach from a logistics perspective, but there is another reason. In this new era, it is important for as many executives as possible to hear what investors are saying. If investors are close by, it will be easier to sign up executives for the meeting. Their understanding of investors will be crucial in developing the ongoing marketing strategy.

Ingredients for a Successful Campaign

Have you hired a professional marketing firm to hone your corporate messaging, branding, market positioning, and value propositions? Have you allocated funds to create your marketing materials? At a minimum, every life science firm should have a logo, tag line (6-12 words that nets out your products/service’s value), elevator pitch (3-4 high level sentences that describe exactly who you are and what you do), executive summary (1-2 pages tops), a power point (10-12 pages tops), and website that is used as a fundraising and scientific information tool. This collateral is absolutely necessary in the game of fundraising in the life science arena.

In addition, you must budget to fund an ongoing marketing campaign that includes travel, purchasing lists, subscriptions to investor database services, investor road trips, and attending seminars and industry events. To raise money you have to spend money.

Firms that try to save money by cutting corners or producing collateral themselves will inevitably learn some hard lessons. The most important of these lessons is that they are not able to effectively compete with their peers that have done it right from the start by making the investment. The second lesson is that they wasted valuable time trying to be a marketer, graphic designer, and content generator. Last but not least, they realize that their campaign has created the wrong impression in the minds of target investors.

The competition for life science investment dollars is stiff. An investor today can receive upwards of 100 unsolicited e-mails and 100 unsolicited phone calls per week. To differentiate yourself from all the “noise,” your messaging has to be spot on.

Understand that marketing collateral is a direct reflection on the ownership of the firm. Your firm’s commitment to fundraising cannot appear frivolous, cavalier or, even worse, novice. Investors want life science firms who are savvy and understand that every aspect of their firm will be intensely scrutinized and that the management team’s professionalism is as important as firm’s concept and business model.

The Global Target List (GTL)

Another key component for a life science firm’s marketing campaign is the Global Target List (GTL). A GTL is a list of all prospective investors that are a good fit for a life science firm’s product. Creating a GTL is one of the most critical steps in the fundraising process; some marketers will make the mistake of attempting to reach out to as many investors as possible in hopes that they will stumble upon investors who are a fit for their firm. This methodology wastes time and resources for both the firm’s marketer as well as the investor who is receiving hundreds of similar solicitations on a weekly basis. Thus, by creating a GTL, a marketer can identify and engage investors that are potential allocators in a much more efficient manner than marketers who are blindly canvassing the investor universe.

Attempting to identify the appropriate investors to contact can be a challenging endeavor. However, a life science firm’s marketing team can roughly gauge the types of investors that would be most interested in their product based on its stage of development. Family and friends, as well as angels typically provide capital for products that are in the R&D phase, or are in the pre-clinical stage of development. Family, friends, and angels are more likely to make allocations at the earliest stages of the product’s development because they may be less risk averse than more institutional investors, and these investors may have a personal connection with the product’s development team, which makes them more willing to invest in the earliest stages of a product’s life cycle. Angels are also often times willing to provide capital to firms that are in phase one of clinical trials. However, because they generally make allocations that are less than $1 million, angels typically do not participate in making investments into products in later rounds of the development cycle due to the large amount of capital that is required. The main play for angels is interest in product or service, being able to participate with management team boards, and minimal investment for outsized returns.

Family offices and foundations as well as venture capital funds (the few that remain active) typically invest in products that are in the pre-clinical stage; or those that are in phase one or two or clinical trials. Large pharmaceutical and biotech companies are increasingly shying away from investments that are in the pre-clinical stage of development due to the amount of risk involved in these types of products. Thus these types of investors typically will only invest in products that are going through clinical trials, whether they are in phase one, two or three of this process. Private equity tends to focus its capital further down the pipeline as well, largely due to the small ticket size and high risk of early stage plays in life sciences. Firms that are attempting to compile a GTL can thus get a rough idea of the kinds of investors they should be reaching out to based on their product’s development stage. However, in order to create a more targeted list, the firm would have to obtain information regarding the investor’s area of interest in the space.

Moreover, due to the availability of capital in the past, life sciences CEOs are used to putting on their “fundraiser hats” when capital is needed, and returning to their primary duties of developing product once it has been raised. This approach no longer makes sense in today’s market, where investors need to be courted over longer periods of time through the establishment of a dialogue and relationship. Therefore, it is important not only to have a target list focused on present capital needs, but also future capital needs. CEO’s should focus outbound fundraising efforts not only on the investor base that is a good fit for current capital raise efforts, but also those that will be a good fit two or three capital raises further down the line. Establishing this dialogue early streamlines the financing of the organization over time, reducing the amount of effort and resources required for fundraising over the organizational lifecycle. This lets the company focus on what is most important: bringing product to market.

EBITFundraising Campaigns Are Dynamic

You have your goals, your plan, and your materials. As soon as you launch, something will change. Guaranteed. Do not despair; it is the nature of the fundraising beast. Learn, adjust, and continue on.

If you fall short of your campaign goals, regroup and set new milestones. If you discover a problem with your plan, rework it. If investors raise questions not covered in your power point, revise it.

Too often marketers make the mistake of adhering to the same investor pitch, despite clear signals that it is lacking in some way. Your power point is a work in progress. If investors ask the same questions over and over, change your presentation so it addresses them in future meetings. The fundraising team must be open and ready to change tactics and try new things. The power point should evolve along with your marketing campaign. It is part of understanding and adjusting to your market.

Investors want to see how firms work month-to-month and quarter-to-quarter. They expect life science firms to report not only on reaching product development milestones, but also to forecast monthly and quarterly goals ahead of time. Firms’ victories and defeats will serve as a barometer of the executive team’s experience and proof of their strategies.

Life science firms that are able to build a sustainable relationship with market-wary investors will attract future investors. Life science firms that are able to learn from mistakes and adapt in real time will secure allocations. Investors on the whole are a forgiving group, as long as the facts are on the table and all assumptions and rationales are vetted. They will not tolerate doubletalk when it comes to explaining good or bad non-attained plan performance.

Marketing Is a Numbers Game

Here is a rule of thumb for direct outbound marketing: 1,000 targets (good, clean targets) yields 100 leads, which produces 10 qualified leads, and generates one to two deals. If you purchase a list with 1,000 names, and 20 to 30 percent of the data in a list is inaccurate, your marketers are being set-up to fail. According to these direct marketing statistics, they do not have enough prospects to call to make a sale.

Another important fact is that people fail in marketing their firm because they do not follow-up. A study published by Herbert True, a marketing researcher at Notre Dame University, noted the following:

44 percent of sales professionals quit trying after first call
24 percent quit after the second attempt
14 percent quit after the third call
12 percent quit trying to sell a prospect after the fourth call

This means that 94 percent of sales executives quit before the fifth call. The irony of this is that 60 percent of all sales and sales connections are made after the fourth call. Mapping this report to the practices of your own in-house marketing team may mean life or death for your fundraising efforts. The overwhelming majority of marketing professionals don’t give themselves the chance to sell their own product.

In short, the two main reasons why firms fail to raise capital are that they waste time targeting the wrong investors and do not understand how to reach out, make contact, create a dialogue, and grow a relationship with investors.

Summary

The fundraising game has changed. In today’s environment, raising capital must be an integral and ongoing part of a company’s business strategy. Unfortunately, many senior executives have not evolved their fundraising strategies to meet the needs of the new landscape. They must adapt to the realization that investors no longer come to promising life science firms with checkbooks in hand.

Those days are long gone. If your firm is navigating the future by looking at a historical map, you will not be successful. Worse still, if raising capital is not at the top of your corporate agenda today, you will be playing catch-up tomorrow. And that will be an even bigger drain on your firm’s human and capital resources.

Continuous fundraising is a big commitment. First and foremost, it takes time, money, and resources (if you are focusing your firm’s marketing campaign regionally it may cost $40,000-$60,000, while global campaigns could cost upwards of $80,000-$120,000). Then there is the execution and follow-up. However, while many investors are still on the sidelines, they will not be there for long.

Now is the time for life science firms to jump-start outbound marketing efforts, find investors that are fits, engage them in a compelling dialogue over three to four quarters, and provide them with collateral materials and reports that help them understand your operations and plans for success.

Life science firms that recognize the rules have changed and react proactively, will successfully raise capital and build their investor base.

About Life Science Nation

Life Science Nation (LSN) is a sourcing platform for market intelligence and prospect pipeline development in the life science arena. LSN enables life science professionals to generate a list of qualified global targets that are a fit for their company’s products, services, and fundraising efforts.

As a leading B2B source for decision-maker contacts in the life science industry, the LSN platform has more than 24,000 life-science organizations worldwide, including biotechnology, pharmaceutical, medical technology, service providers, suppliers, nonprofits, and investors. The LSN platform utilizes the most extensive research and data mining techniques to provide deep insight into target markets, top-tier accounts, and global business opportunities and help clients earn a measurable ROI on their marketing investment.

Contact

To learn more about Life Science Nation please contact,

Life Science Nation

9B Hamilton Place

Boston, MA 02108

Phone: +1 (617) 600-0668

Email: info@lifesciencenation.com

[1] Silicon Valley Bank, “Continued Rebound: Trends in Life Sciences M&A”, July 18, 2012

[2] Silicon Valley Bank, “Continued Rebound: Trends in Life Sciences M&A”, July 18, 2012

[3] Madison Park Group, “Guide to Venture Capital”
Posted on November 27, 2012. | Tagged biotechnology, consulting, family offices, fundraising, investor, life science nation, medicine, pharma, private equity, research & development, startup, venture capital | Leave a comment | Edit

Introduction to Life Science Nation – Dennis Ford, CEO

3 Dec

Hello World!

As CEO of Life Science Nation (LSN), I am happy to announce the launch of the LSN Newsletter.  The goal of LSN is to help bridge the gap between science and business. LSN provides a sourcing platform that facilitates the identification and aggregation of current accurate prospect lists for sales, marketing, business development and fundraising executives within the life science arena.

LSN’s mandate is to help solve the sourcing problem that slows down the life science industries marketing efforts as a whole. The goal is to help sales and marketers sell more, business developers to find top candidates for strategic alliances, and fund raising executives to pinpoint capital that is a fit for their stage and products or services.

Adroit marketers understand the two paramount rules of success: know your product, and know your prospective customer. LSN is the source for identifying who is the perfect fit for your profile of a prospective client. The value of creating an accurate profile of who is a precise fit for your product, service, or fundraising campaign makes the marketing initiative more effective and efficient.  LSN was created to fill the void that exists in the life science industry when it comes to sourcing quality marketing intelligence.

Thank you for reading our newsletter, and I look forward to working with you!

Dennis Ford

CEO, Life Science Nation

Prospect Pipeline Development for Product and Service Providers

30 Nov

by Brian Gajewski, VP of Sales, Life Science Nation

The uncharted nature of emerging biotech makes it an extremely difficult space to navigate. New start-ups are not initially on the industry radar screen and big pharma projects are buried in the corporate maze. Product and service marketers typically spend 20% to 30% of their time generating new leads and qualifying prospects. CRO marketers often comment to Life Science Nation staff that an inordinate amount of time is required because the marketers are looking for the proverbial needle in the haystack—active biotechs and small projects within big pharma firms who are interested in their particular niche product or service. Regardless of whom your target is, life science marketers spend an enormous amount of time trying to find good prospects.

Conversely, emerging biotechs and big pharma have a difficult time sourcing reliable, top-quality product and service providers. Traditionally these entities have three ways for their internal staff to ferret out and vet these providers: word of mouth, information portals like Google, and partnering conferences. Still, it’s a time-consuming, brute force effort. The well-known data and information providers in the life science industry do little to help these marketers. None really track the small projects at big pharma well, and most small start-ups do not have enough size to fit the tracking metrics of the large data houses, so they are overlooked. Life Science Nation solves this “sourcing dilemma” by offering a platform integrated with a life science ontology that enables marketers – with just a few clicks – to effectively and efficiently connect with emerging biotechs and “small” big pharma projects.

Life Science Nation gathers data on more than 24,000 life science organizations, including biotech, pharma, medtech, service providers and suppliers, public/nonprofit organizations, and life science investors. Regional biotech clusters, economic development councils and life science conference show providers contribute to and utilize the database to maintain their online membership directories, and leverage the sourcing platform to gain visibility. This grass-roots aggregation allows LSN to identify and add emerging companies to the database very early on in their start-up cycle.

Life Science Nation offers the best of both worlds with its comprehensive coverage of all the large and small companies in the life science industry—whether that is keeping up to date with the large players or finding the latest small, innovative companies that will be the stars of tomorrow.

Valuation – What You Need to Know

27 Nov

By Patrik Frei & Benoît Leleux

Valuing a company has always been more art than science. In this article, we provide a basic outline of how to conduct a proper valuation exercise and present two common methods used to value an early stage biotech company.

Gauging value

A company’s value lies in its potential to generate a stream of profits in the future. All valuation exercises are thus based on envisioning a company’s future, relying almost entirely on educated guesses. Value is based on assumptions as to what a company’s future may look like, what important milestones will have to be met and strategic decisions taken. These assumptions are grounded in three fundamental factors: first, the state of the market targeted by the company; second, the principle elements of a company’s science and technology; and third, the ability of management to deliver on the business plan. We would recommend that every valuation start with a systematic and rigorous testing of a company’s economic, technological and managerial hypotheses in combination with the following two key approaches:

• Primary valuation, which is based on such fundamental information as projected future free cash flow (FCF) and costs of capital;

• Secondary valuation, which is based on comparable information, where valuation is done by analogy to other similar companies.

With a good understanding of the above two approaches, an entrepreneur is already well equipped to tackle the negotiations that will ultimately determine the deal valuation.

Fundamental valuation

The most common approaches to primary valuation in the corporate finance literature are generically referred to as the discounted cash flow (DCF) methods, whereby a company is valued at the present value of the future cash flows it will be able to generate. These methods are conceptually robust but can prove difficult to implement in high uncertainty environments, such as those of early-stage biotech firms. Typical problems include highly uncertain and distant positive cash flows, a business model based on many assumptions and a difficult risk profile. Corporate finance theory indicates that the value of any asset is equal to the present value of its future cash flows. Therefore, in principle, all that is needed is (i) to estimate the expected future cash flows of the business, and (ii) to discount back to the present all these future cash flows, using a discount rate consistent with the level of risk in the project. In practice though, problems emerge at every step of this process. First, projecting performance for several years into the future is a process seen by many as too speculative to be useful. Second, selecting a forecasting horizon for the future cash flows (5 years, 10 years or 20 years) is purely arbitrary and leaves open the question of the residual value of the business at the end of that horizon. Third, obtaining an appropriate discount rate for an early-stage, privately held company presents difficulties.

Projecting cash flows into the future is never an easy endeavor, especially for smaller, high-growth life science firms. The key data used for valuation is the FCF. According to Copeland, Koller and Murrin (1), “[FCF] is a company’s true operating cash flow.” In other words, the FCF refers to the cash flows free of (or before) all financing charges related to the corporate debts. These cash flows include all necessary fixed asset investments and working capital needs, as both are normally needed for a viable business. The FCF is estimated through the financial projections of the business plan. Depending on the available information and the time frame needed for a steady revenue flow, a forecast period of 5 or 10 years is most commonly used.

Table 1The easiest approach to determining the most appropriate discount rate in a DCF is one that would use the stage of development of the company, which can be determined by the drug development stage of products in the pipeline as proxies for risk (see Table 1). For example, a company that is generating leads without further developed products would be considered a seed stage company and a discount rate of between 70%–100% would be used. Although conceptually a bit loose, the method is surprisingly reliable. Several factors typically influence the risk profile of a biotech company. Once identified, the risk factors can then be used to determine the discount rate within the ranges provided in Table 1. The discount rate to be used in a DCF calculation depends on the degree to which a company fulfills each of the criteria. As the discount rate is critical in determining value, it is appropriate to spend time in meticulously assessing each criterion and to investigate the sensitivity of the results to the various parameters.

Comparable valuation

The comparable method is also known as a “secondary” valuation method because it uses the market value of comparable companies or transactions as reference points. The method relies on available key figures, such as earnings, sales, number of employees, number of PhD’s or R&D expenditures, to estimate value. In a sense, secondary valuation makes the assumption that these comparable companies have been properly valued, and can serve as benchmarks when assessing a company. For example, if a comparable public company is valued at $1,000 with R&D expenditures of $500, for a price/R&D ratio of 2, then the private company to be valued with R&D costs of $200 would, by analogy, be worth an estimated $400.

Closing remarks

Humility and realism are the two key attributes of the prospective company valuator. Humility is needed to recognize that the exercise is primarily about envisioning the future, and that the exercise is fraught with uncertainty. Realism will help to understand that the inherent uncertainties do not constitute an excuse for sloppy estimates of the valuation components. Whether the valuation is done explicitly (as in the DCF methods) or implicitly (as in the comparable methods), either method will give an accurate valuation if carried out by experienced valuators.

Although the valuation methods described here are routinely used by investors, we offer three important cautionary remarks to help the newcomer to watch for typical pitfalls. First, investors often refer to pre- and post-money valuations: pre-money is the value before the investment is included; post-money is the value including the new investment. Thus, pre-money value + investment = post-money value. Investors routinely play with different figures and company data. Numbers are their daily business and they may try to use them to their advantage.

Second, don’t enter into negotiations without having completed your homework. Management needs to master the figures and numbers and have clearly laid out its expectations about pre- and post-money value and the corresponding value of its shares. Only with preparation and a good understanding of valuation drivers can management establish itself as a credible partner in front of investors.

And third, valuation is not everything. The investment contracts that accompany investments can easily take away everything that was given in a rich valuation, by imposing drastic restrictions on the future conduct and wealth of the founders. Similarly, a company must feel comfortable with its investors because they will share the same bed, figuratively, for a long time to come. It would thus be foolish to maximize the short-term share price if it is at the cost of the long-term value creation potential of the company. Never lose track of the fact that a financing round is just a means to an end, not the end itself!

Patrik Frei is the CEO of Venture Valuation

This story was reprinted with some modification from the Building a Business section of the Bioentrepreneur. Web portal: (http://www.nature.com/bioent), 21 June 2004, doi:10.1038/bioent814.

1. Copeland, T. , Koller, T. & Murin, J. Valuation: Measuring and Managing the Value of Companies.(John Wiley & Sons, New York, 2000).

2. Frei, P. & Leleux, B. Valuating the company. In Starting a Business in the Life Sciences—from Idea to Market. (Luessen, H. (ed.).) 42–55 (Edition Cantor Verlag, Aulendorf, Germany, 2003).

Family Offices’ Direct Investment in Life Sciences — The Perfect Storm

27 Nov

By Max Klietmann, VP of Research, Life Science Nation

In the wake of the turbulence caused by the financial collapse and global recession, family offices have become discouraged by the performance of their allocations in alternative asset classes such as hedge funds and private equity. As fund managers struggle to justify handsome management fees for poor performance, many sophisticated family offices are beginning to take their alternative allocations in-house. Though many in the space predicted this to be a natural trend given the circumstance, circumstances aside, this is a trend which is better aligned with the ultimate mission of the family office when strategically deployed in life sciences. The convergence of several defining characteristics of family office investors and the recent developments in life sciences are creating a perfect storm that will surely change the industry in a major way.

To begin, lets consider the primary mission of a family office: to maintain a family legacy through capital preservation and philanthropic engagement. This dual mandate is the major differentiator for family offices versus any other investor group. It is for this reason that the life sciences are so appealing.

Life sciences constitute one of the single best performing sectors available to investors. The industry is growing at an unprecedented pace, and it is one of the only sectors that were able to maintain strong positive growth throughout the recession. According to one large multi-family office in Boston, a significant portion of client assets that were allocated to alternatives are now being deployed directly. However, due to the sophistication of the family office investor, this capital behaves much differently than angel capital and is truly globally oriented.

Another reason that life sciences are so appealing is that from a philanthropic perspective, investment in life sciences provides an opportunity to allocate capital in a much more productive manner than via foundations or charities. Without question, those organizations are extremely valuable, but they simply cannot compete with the potential social impact of a breakthrough scientific discovery. This is especially true when one considers that many family office’s philanthropic mandates are influenced directly by health conditions prevalent in the family.  It becomes a compelling argument to invest directly in emerging technologies targeted at treating or eradicating those diseases.

Finally, there is the overall theme of investing with a legacy in mind. Life sciences are a field committed to finding the solutions to many of society’s gravest ailments. It is natural for family offices to desire to be a part of something on the scale of life sciences in that it provides potential for them to create a lasting impression on the world in their name.

About Life Science Nation

Life Science Nation (LSN) is a sourcing platform for market intelligence and prospect pipeline development in the life science arena. LSN enables life science professionals to generate a list of qualified global targets that are a fit for their company’s products, services, and fundraising efforts.

As a leading B2B source for decision-maker contacts in the life science industry, the LSN platform has more than 24,000 life-science organizations worldwide, including biotechnology, pharmaceutical, medical technology, service providers, suppliers, nonprofits, and life science investors. The LSN platform utilizes the most extensive research and data mining techniques to provide deep insight into target markets, top-tier accounts, and global business opportunities and help clients earn a measurable ROI on their marketing investment.

Contact

To learn more about Life Science Nation please contact,

Life Science Nation

9B Hamilton Place

Boston, MA 02108

Phone: +1 (617) 600-0668

Email: info@lifesciencenation.com