Texas Medical Center to Host Redefining Early Stage Investments Conference

By Dennis Ford, Founder & CEO, LSN

BOSTON – February 19, 2015 – Life Science Nation (LSN) and Texas Medical Center (TMC) have partnered to bring the Redefining Early Stage Investments (RESI) Conference to Houston on June 8, 2015. The conference will take place at TMCx, the TMC’s 100,000+-square-foot, state-of-the-art accelerator space.

RESI @ TMCx will bring together fundraising CEOs and early stage investors from around the globe, providing the opportunity for dialogue and relationship building, with the goal of eventual capital allocations.

“TMC has long been known for world-class life science research and technology,” said Dr. Robert Robbins, President and CEO of TMC. “RESI @ TMCx will bring early stage global-investment capital to our accelerator space, which will hopefully streamline the commercialization of our technology assets.”

The RESI conference focuses on 10 categories of early stage investors. Through an expansive series of panels and workshops, investors explain their current investment mandates and process for identifying and qualifying candidates. The RESI Partnering Forum employs a Match.com-like sourcing platform that fundraising CEOs use to identify life science investors who fit their technology sector and stage of development.

RESI @ TMCx will feature angel syndicates, family offices and private wealth firms, corporate venture capitalists, venture philanthropy groups, foundations and endowments, big pharma and virtual pharma companies, mid-level private equity firms, government organizations, and venture capital investors.

“RESI is a very efficient venue for investors and innovators to find each other,” said Dennis Ford, CEO of Life Science Nation, the creator of the RESI conference series. “Our vision for the series is to provide, a venue for early stage investors and innovators to connect.”

RESI Boston takes place in September, followed by RESI San Francisco, which is held in concert with the JPMorgan Healthcare Conference in January. RESI @ TMCx will become the third conference in the series.

 

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About Texas Medical Center

The largest medical complex in the world, the Texas Medical Center is internationally recognized and home to many of the nation’s best hospitals, physicians, educational institutions, researchers, and the largest concentration of life-sciences experts. For the first time in its history, the Texas Medical Center has aligned the multi-institutional expertise to formulate five institutions dedicated to: Health Policy, Clinical Trials, Regenerative Medicine, Genomics, and Life Science Innovation. Together, these institutions will advance the Texas Medical Center as the global leader in human health and life sciences.

About Life Science Nation

Life Science Nation (LSN) accelerates the funding of early stage life science firms through its Match.com-like sourcing platform for private investment and enables CEOs to be more efficient in their capital-raising efforts. LSN owns and operates the Redefining Early Stage Investments (RESI) conference series.

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PR Contact:

Nono Hu
Marketing/PR Manager, Life Science Nation
(617) 580-5011
m.hu@lifesciencenation.com

10 Family-Office Speakers Shed Light on Direct Investing in Therapeutics and Medical Devices

By Michael Quigley, Director of Research, LSN

mike-2Last month in San Francisco, Life Science Nation’s RESI Conference hosted two family-office panels to discuss investors’ motivations for funding therapeutic and medical-device companies, the current trends in this space, and the distinctions between family offices’ investment strategies. Given the fact that a good portion of family offices fly below the radar, it is easy to understand why there was standing room only during these two panel discussions.

LSN recruited the panelists from our extensive network of family office investors—a network that we have developed over the past three years. As noted by both panels, family offices have been increasingly making direct investments in life science companies, a trend LSN has been following.  The reasons for this trend include avoiding poor returns (as happened during the financial crisis), increasing control over the final investment decision, and having a philanthropic and social impact. Last but not least is the personal aspect, where some family offices are also looking to provide solutions to their own family healthcare issues and thus effecting the family legacy.

Both panels stressed numerous points, including the importance of companies having a strong management team, the growing sophistication of family office investors, and the generally longer investment time lines that these investors have. The latter trait in particular means that, in many cases, a family office can more successfully align with the goals of a fundraising entrepreneur than can many other investors.

Other topics discussed by the panels included strategies and channels for finding family offices, best practices for securing funding from these investors, and the strategic benefits that family offices can bring to the table after committing capital.

One fact that echoed in these panels is that family offices represent a significant, valuable source of capital that should be strongly considered by any fundraising entrepreneur. To see for yourself, take a look at the video recaps of the panels.

 

Tales from the Road: Four Entrepreneurs Share Their Advice on Fundraising

By Lucy Parkinson, Senior Research Manager, LSN

lucy 10*10What’s it like to be in the driver’s seat of an early stage fundraising campaign? At the recent RESI Conference, LSN brought together four life-science executives for a “Tales from the Road” workshop to hear their firsthand accounts of navigating the fundraising process and raising capital. What stumbling blocks had they hit, how had they solved the issues, and what had they learned about raising capital? How did they go about finding potential investors, and how did they determine which investors they should pursue?

Here are the make-or-break points that our entrepreneurs stressed.

Having the Right Team

As Shantanu Gaur (CSO, Allurion Technologies) explained, the quality of the management team is particularly important when a very early stage company is raising capital. Before a company plots a development timeline, acquires data, talks to regulators, or makes a business projection, the company begins with a management team and an idea. Seed-stage investors therefore focus on the quality of the management team and the potential of the idea. Given that Shantanu was a young entrepreneur—he had not yet graduated from medical school—he built a team with “plenty of grey hairs” that could provide the industry experience he lacked. This team was able to convince investors that it was the right team to advance the idea and realize its full potential.

In addition to experience and the ability to appeal to investors, the entrepreneurs on our panel mentioned two other ways in which having the right management team is an absolute necessity.

First, many life-science companies raise money from friends and family to turn the lights on before gearing up for their first institutional financing round. If the individuals on a management team have strong personal networks, those contacts can become initial sources of support.

Second, raising capital requires having a staff that is not only dedicated to the fundraising process but also has the wide range of skills required. Rick Berenson (CEO, Thermalin Diabetes) noted that although it’s vital to have a team member who’s strong at pitching, there must also be a team member responsible for meeting logistics and chasing investors for follow-up discussions.

Following the Four Steps to Raising Capital

Rick Berenson explained the four steps of the fundraising process (Rick calls these the ‘four Ss’): sourcing investors, screening investors, segmenting investors, and selling to investors.

Several of the panelists had successfully made use of the LSN Investor Platform to connect with investors outside of their existing personal networks. This particularly rings true in the family office space, where panelists said it was often hard to find an initial contact. Other sources panelists mentioned included Gust.com, local angel networks, and lists of major donors to charitable foundations in the relevant disease field.

The next challenge, as Kurt Dieck (CEO, Biosortia Pharmaceuticals) put it, is identifying the few investors who will be willing to sign a check from a global target list of potentially hundreds of investors. This is the process of screening investors. How do you decide who to prioritize? Here, the entrepreneurs told us that investor fit plays a key role, often in a way that becomes more nuanced than simply being in the right indication area and phase of development. For example, if your company’s strategic plan involves global regulatory approval and sales, a globally active investor will be a better fit than a regional investor. Again, having the right team is vital; a campaign can be run far more efficiently if there is a team member dedicated to qualifying investor leads, finding the alignments between the company and each investor, and sending out personalized teasers to get an investor’s interest.

It’s also important to keep an eye on an investor’s mood; does the investor seem excited to have follow-up meetings with you, or do you seem to be last on his or her priority list?

Frederick McCoy (President and CEO, NeuroTronik) pointed out that the screening process goes both ways—which of the investors you’re meeting could you picture as being involved with the company after the financing round has closed? Which investor would make a strong board member, or a relevant strategic advisor?

Segmenting interested investors is the third step. When will each investor be willing to get involved? Rick Berenson noted that raising capital in life sciences is like making a movie in Hollywood: what gets investors interested is knowing that other investors are interested. Some investors like to declare their interest early, taking a risk in return for a commensurate reward. Others want to see who else will come in before joining to close out the round. And still others may pass until the next round, while they keep in touch and watch your progress.

Finally, with all your targets in line, the last step of the process is selling to investors.

Recognizing That Fundraising Is Selling

What is fundraising? According to Rick Berenson, fundraising is a sales process, and it’s therefore about overcoming all of the possible objections to close a deal. An early-stage life science company has to sell investors on complex, cutting-edge technology.  The sales process for an early-stage fundraising campaign therefore involves making the investor comfortable with the risks involved.

One persistent difficulty the entrepreneurs identified was that of unvoiced objections; it’s hard to make an investor more comfortable about a concern if he or she hasn’t told you what it is. Shantanu Gaur told the audience that it often takes many meetings for these problems to be voiced—and then more meetings before the investor becomes comfortable with the answers.

But is it possible to preemptively address these problems? Kurt Dieck suggested exploring with investors all the initial objections you had to pursuing your technology. Tell investors how you overcame each cause of skepticism and why you’re now excited to be part of this opportunity!

The entrepreneurs also explained the importance of tailoring pitch content to the audience. Fred McCoy suggested beginning with a top-level pitch deck and letting investors ask deeper-level questions. That way, you can lead each investor through the fine points that matter to them—whether it’s a question of pharmacokinetics, regulatory pathways, or financial projections. In this way, you will appear confident on the details while not overwhelming investors with details that aren’t of concern to them.

Finally, Rick Berenson advised to be sure to speak each investor’s language. If you only speak to investors in the language of a scientist, the message won’t get across; by being adaptive and engaging in their own language, you have the opportunity to build a real connection.

[Video] LSN Fundraising Boot Camp at the 10th Non-Dilutive Funding Summit

By Dennis Ford, Founder & CEO, LSN

I recently presented a Fundraising Boot Camp at the FreeMind Group’s 10th annual Non-Dilutive Funding Summit in San Francisco, to an audience comprised of scientist-entrepreneurs and fundraising CEOs. LSN’s Fundraising Boot Camp helps create context and understanding for these entrepreneurs around issues related to branding and messaging of their firms. The presentation also explains why organizing a global target list of investors that are a fit for your sector and stage is vital to an efficient fundraising process.  Last but not least, I discussed and debunked some of the myths around fundraising, what works, and what doesn’t work.
Check out the video to learn more.

RESI 4: A Recap

By Lucy Parkinson, Senior Research Manager, LSN

lucy 10*10In January, RESI came to San Francisco for the JP Morgan Healthcare Conference week.  LSN was thrilled that so many of you were able to join us there on January 13th; over 500 attendees registered for RESI –  our largest crowd to date.  RESI 4 provided four all-day content tracks outlined in the RESI 4 Program Guide. Even attendees may have missed out on some of the excitement; our video recap below can fill you in on the full scope of the event.

 

This audience provided a vibrant mix of life science industry executives. Figure 1 shows what type of firm each attendee represented:

Figure 1 | Data as of January 13, 2015

The most striking fact about this breakdown is that the investors outnumbered the attendees from biotech and medtech startups.  The pre-existing relationships with investors and strategics developed by LSN Research and Business Development staff garnered over 200 investor registrations at RESI 4.  These investors were keen to book meetings with entrepreneurs and assess their innovative technologies; almost 60% of the meetings booked on the RESI Partnering system were between investors and entrepreneurs.  Here’s a closer look at who took meetings with whom at RESI 4:

Figure 2 | Source: RESI Partnering Platform, Data as of January 13, 2015

Interestingly, investors booking meetings with fellow investors was the third most common meeting type.  This continues a trend we’ve noticed at previous RESI events: investors are interested in meeting with each other to discuss potential syndication or strategic opportunities, or possibilities for future collaboration.  RESI is a stellar venue to facilitate these meetings, given how many investors are present; RESI also offers investors the opportunity to use the RESI partnering platform to hone in on investors with common strategic interests in terms of indication area or stage of development focus.

RESI provides two core experiences; the opportunity to hear investors outline their mandates and methods of investment at RESI’s panels, and the opportunity to hold partnering meetings with fellow attendees.  By gathering so many luminaries in the early-stage life science world together under one roof, RESI creates an atmosphere that leads to a huge number of ad hoc meetings – more than we could count.  Whether it’s after a panel, at the reception, or in the exhibition hall viewing the RESI Innovation Challenge, LSN witnessed attendees engaging with each other in a highly productive environment throughout the day.  With more investors than early-stage entrepreneurs present, RESI 4 provided life science startups with an excellent opportunity to network with early-stage investors who are relevant to their fundraising campaigns.

RESI continues to innovate, with a new array of panels including a track devoted to medical technology investment.  LSN looks forward to bringing RESI to new venues in the future, and to returning to San Francisco in 2016.

A Guide to Researching Life Science Investors

By Michael Quigley, Director of Research, LSN

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For nearly 3 years the LSN research team has been identifying, profiling and interviewing early stage life science investors from around the globe. Throughout this time we have developed and honed a process for the identification and validation of investors in order to understand and qualify their investment interests. I recently held a “Researching Global Investors” workshop at our RESI 4 conference to shed light onto this process and share the tools and resources that we use, so that the entrepreneurs in the audience can take advantage of them as well. This article mirrors the workshop to further spread the message to our readership.

Tools for Identification:

Understanding where to look to find potential investors can seem like a daunting task given the vastness of the internet; however, by understanding the tools at your disposal, you can dramatically increase the effectiveness and efficiency of your research. Google search is often underutilized by those unaware of its capabilities. The chart below shows some basic “boolean” operators that can dramatically increase the precision of your searches.

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These functions can be entered into the Google’s search bar to make your searches are more targeted and fruitful. For example, by entering  (intitle:biotech AND “Invest” AND “Early Stage” –public) into Google, you can search the web for sites and articles that have “biotech” in the title, include the terms “early stage” and “Invest”, and do not include the word “public”. Boolean functions should be utilized in whatever way makes the most sense for your campaign; this could include looking for terms surrounding your indication, stage of development, geographic exposure, or other factors that define your opportunity. By executing a number these searches and diving through a few pages of results you are sure to come up with a size-able number of potential investors.

Another often underutilized tool is LinkedIn. Similar to Google, LinkedIn search is also compatible with boolean operators, so using these in the search can again improve effectiveness. LinkedIn also offers an Advanced People Search feature that includes keywords, company name, industry and location among other details, as seen below. An additional benefit of using LinkedIn is that investors and others who are active LinkedIn users with complete profiles are often more open to being approached with opportunities. As LinkedIn is a professional networking site, these individuals tend to be more open to new contacts, and may even be actively looking to expanding their networks and uncover new opportunities.

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Additional sources for new investor leads include life science investor conferences, and the websites of companies similar to your own. Investor conferences often list attending investors on their webpages, so even if you cannot attend an event, these can be great sources for identifying active investors. Much like investor leads found on LinkedIn, investors found on conference lists tend to be actively looking for new opportunities; this is generally their motivation for attending the conference. Now, visiting similar companies’ websites to find investors may seem like a stretch; however, many companies list their investors on their website, and if they are in a similar space and stage as your opportunity it is highly likely that those investors are a great fit. Also, many companies list their board of directors on their webpage as well; oftentimes members of the board are investors, as investors generally look to take a board seat following investment.

Validation:

Once you have identified a number of potential investors using the aforementioned methods, you must validate that these investors are a good fit for you opportunity. There are several variables you should consider, the first of which is determining if the investor is currently allocating. When attempting to determine if an investor is currently allocating you want to look for the most recent new investments that investor has made. These can be found either on the webpage of the investor or through using Google searches to find press releases or media articles relating to the investor’s recent deals. The more recently the investor has made a new investment, the more likely that they are still currently investing. Another means of identifying investor activity is to look at the most recent fund vintage. Funds generally have a 10 year lifecycle from closing until they need to return capital to their limited partners. As such, if your company requires 3-5 years to reach a potential exit, you will want to identify funds that have closed no more than 5 years ago. Funds generally reserve capital for follow-on investments, so it is highly likely that funds greater than 5 years old are no longer making new investments at all. They are instead reserving the fund’s remaining capital to support current portfolio companies.

Other variables that require validation include the investor’s preferred stage of development, industry sector, indication areas and geography. While many investors also list these criteria on their webpage, others are more reticent. For investors who do not list their criteria on their web page, the best place to look to find it would be in the firm’s previous investments. Have they invested in medical devices, or in therapeutics? Do they only invest locally, or will they look at opportunities globally? Do they invest in series A rounds, or are they only investing in later stage companies? Many of these questions can be answered by taking a look at previous investments the investor has made. Information on these previous investments is often available in press releases that can be found through searching the web.

The type of investor you are researching can also be a telling sign of the stage of investment they are looking for. The chart below provides a visual representation of the different stages of therapeutic development that different classes of investors are generally interested in.

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Having a validated list of potential investors is extremely valuable, and this process is usable by virtually any fundraising entrepreneur in the life science industry. The fact that investor and company fit is an extremely important precursor variable into building a successful relationship that could lead to an an allocation. is the reason why this process is valuable, and is a fact that LSN’s Research and Business Development staff have seen the value of fit proven in the marketplace time and time again. Through this process outlined above, the research team at LSN has been able to identify thousands of life science investors and our number of investor profiles is still growing.

If you wish to see the presentation slides, click here.

Asia-Based Investors Are Increasingly Seeking Global Innovation

By Michael Quigley, Director of Research, LSN

mike-2In tracking life science investors worldwide, LSN’s research team has noticed that there are a growing number of Asia-based investors seeking global opportunities as well as investments in the U.S. and Asia. (See Figure 1.)

 

Figure 1 | Source: LSN Investor Platform, Data as of February 4, 2015

Also worth noting is the number of Asian countries where these investors are based. (See Figure 2.) Although the majority of Asia-based investors are in China, more than half hail from other countries in the region.

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Figure 2 | Source: LSN Investor Platform, Data as of February 4, 2015

Factors Affecting the Trend

Having spoken with more than 50 Asia-based investor groups, we’ve pinpointed a number of factors that are contributing to this trend.

A recurring theme is the lack of advanced infrastructure and practical expertise required to develop technologies in Asian countries. And while “many of the Chinese scientists who came out and studied in the U.S. have gone back to their home country and started their own businesses there,”1 this doesn’t seem to be satisfying Asia-based investors’ appetite for innovation.

Other factors include the booming growth of private wealth that many Asian countries have experienced over the past few years.2 This growth in wealth, coupled with the notoriously uncertain regulatory environment (particularly in China), has led many Asia-based investors to seek a more stable investment environment abroad. Diversification and the potentially high-yield returns this sector can generate also is attractive to these newly wealthy investors.

Arguably the most influential factor that we have heard in our discussions, however, is investor interest in early stage and commercial-stage technologies that are capable of addressing healthcare challenges across Asia as well as in specific local markets.  With growing populations and advancing life expectancy in these regions, the demand for medical devices and therapeutics is expected to increase dramatically—particularly in indications such as diabetes and cardiovascular disease. In fact, the vast majority of investors we have spoken with either require or strongly prefer companies that are planning to or capable of entering their local markets. Also, many of these investors have strong local ties to manufacturing and distribution channels, so they can add significant value to companies entering these markets.

Takeaways for Fundraising Executives

It is apparent that life science companies actively fundraising around the globe should take a serious look at Asian markets for capital. The wealth, population, and average age of individuals are all expected to continue rising in many of these countries. Therefore, the opportunity for life science companies to secure capital is likely to rise as well. Given the cultural differences and distance, starting conversations with these investors as early as possible is key, as the time to close a deal can be elongated by these and other hurdles.

If you are interested in learning more about the investor landscape in Asia and the investors we track, feel free to contact us at mandates@lifesciencenation.com.

  1. “Philip Ma: from Scientist to Businessman,” China Daily, January 23, 2015.
  2. “China Now Has the Second-Most Millionaires in the World,” Time, June 10, 2014.