Next Phase Newsletter

By Nono Hu, Senior Manager, Branding & Messaging, LSN

Yesterday, the sixth Redefining Early Stage Investments (RESI) Conference was held at the Westin Copley Place, Boston. Featuring approximately 200 investors, 250 biotech, medtech and healthcare IT entrepreneurs, and 130 service providers, this event is the biggest RESI ever.

In the exhibit hall, 30 of the most innovative early stage life science companies at the event were chosen to participate in a virtual investment contest – The RESI Innovation Challenge, showcasing cutting-edge life science technologies in poster displays and competing to raise the most RESI Cash. Without further ado here are the top 3 contestants!

First Prize Winner: Rna Diagnostics

Rna Diagnostics is commercializing the RNA Disruption Assay (RDA™) to address the serious problem of over-treatment of cancers with ineffective chemotherapy. RDA accurately assesses effectiveness of chemotherapy in real-time. Chemotherapy effect is assessed as early as 14 days after therapy initiation by quantifying tumour RNA disruption. High RNA disruption is strongly correlated with pathological complete response and enhanced long term disease free survival. RDA assesses treatment efficacy of conventional and targeted cancer drugs in breast cancer. RDA is delivered as a lab developed test service. No FDA approval required. Collaborations and prospective trials of RDA in multiple cancers are underway / planned in North America, Europe & Asia. RDA provides patients with improved outcomes while reducing cost for healthcare payers.

As a first prize winner, Rna Diagnostics will receive complimentary subscription to the LSN Investor Platform.

Alejandro Zamorano, Director of Business Development, LSN | John Connolly, VP Corporate Development, Rna Diagnostics | Michael Quigley, Director of Research, LSN

Second Prize Winner: KIYATEC

KIYATEC prioritizes accurate ex vivo prediction of patients’ drug response, focused primarily on data correlation to human clinical outcomes. Our drug response profiling services utilize phenotypic 3D cell-based models for predicting patient response. KIYATEC’s 3D perfusion tissue microenvironments are particularly useful for investigating efficacy and modeling resistance of cancer therapeutics.

As a second prize winner, KIYATEC will receive two complimentary RESI tickets.

Alejandro Zamorano, Director of Business Development, LSN | Todd Haim, Program Director, SBIR Development Center, NCI | Matthew Gevaert, CEO, KIYATEC | Bryce Chaney, Senior Director of BD, KIYATEC | Michael Quigley, Director of Research, LSN

Third Prize Winner: Synthonics

Metal coordination, or attaching a metal to an active agent to control its absorption and release, represents a significant advance in drug delivery and development. It is a powerful, flexible and elegant means to create a new generation of safer and more effective patent protected drugs (“MCPs”). In addition to imparting a range of desired characteristics, metal coordination enjoys significant regulatory advantages. MCPs of approved drugs are eligible for approval under section 505(b)(2), which allows for faster and less expensive drug development. Moreover, they are patentable as new compositions of matter even if the parent molecule is well known. Synthonics intends to begin human trials in 2016 on its controlled release formulations of levodopa for Parkinson’s disease and liothyronine (T3) for hypothyroidism.

As a third prize winner, Synthonics will receive one complimentary RESI ticket.

Alejandro Zamorano, Director of Business Development, LSN | John Borling, Board Member, Synthonics | Michael Quigley, Director of Research, LSN

Congratulations! We hope to see you at RESI San Francisco on January 12, 2016.

By Dennis Ford, Founder & CEO, LSN 

BOSTON-September 16, 2015 – Life Science Nation (LSN) and MaRS Discovery District (MaRS) are collaborating with Johnson & Johnson Innovation, JLABS (JLABS) to bring the Redefining Early Stage Investments (RESI) Conference to Toronto on June 23, 2016.

The RESI Conference series brings together fundraising CEOs and early stage investors from around the globe, providing the opportunity for dialogue and relationship building, with the goal of eventual capital allocations.

“MaRS supports over 250 Canadian-grown early stage health technology startups,” said Dr. Zayna Khayat, Lead, MaRS Health. “Our goal is to provide these young emerging ventures with the best connections to investors and industry to help them scale internationally. The Redefining Early Stage Investments (RESI) conference series has a strong track record of attracting global early stage investors. We’re delighted to bring them to MaRS in 2016 to build on the success of our HealthKick conferences and support new technologies that will achieve better health outcomes.”

Johnson & Johnson Innovation, JLABS, MaRS, the Ontario Government, University of Toronto and other collaborators announced last week that JLABS will be opening its first ex-U.S. incubator in Toronto. Called JLABS @ Toronto, the site is expected to open in the Spring of 2016. JLABS @ Toronto, MaRS and RESI will connect cutting-edge health technologies with a broad audience of investors and industry leaders including: angel syndicates, family offices/private wealth firms, corporate venture capitalists, venture philanthropy groups, foundations and endowments, pharmaceutical companies, mid-level private equity firms, government organizations, and venture capital investors.

“The MaRS Centre in Toronto represents the 4th venue for our North American RESI Conference series. Now fundraising CEOs and scientist entrepreneurs can meet investors every 90 days – Boston in September (RESI Boston), San Francisco in January (RESI @ JPM), Houston in April (RESI @ TMCx) and now Toronto in June (RESI on MaRS),” said Dennis Ford, CEO of LSN and creator of the RESI Conference Series. “Fundraising is essentially a numbers game and the entrepreneur needs to get in front of as many investors as possible. Having as many as 20 investor meetings every 90 days can dramatically help with funding in the healthcare arena.”

Speakers and participating health ventures will be announced in early 2016.

About Life Science Nation

Life Science Nation (LSN) accelerates the funding of early stage life science firms through its Match.com-like sourcing platform for private investment and enables CEOs to be more efficient in their capital-raising efforts. LSN owns and operates the Redefining Early Stage Investments (RESI) conference series.

About MaRS Discovery District

MaRS Discovery District in Toronto is the one of the world’s largest urban innovation hubs supporting a new generation of makers and innovators who aim to make the world a better place by creating solutions that address key societal challenges. It is a community that encourages entrepreneurial thinking through education programs and events, and helps start-ups launch, grow and scale. MaRS supports over 1,000 ventures.

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PR Contacts: Nono Hu

Marketing/PR Manager, Life Science Nation

(617) 580-5011

m.hu@lifesciencenation.com

Lara Torvi

MaRS Discovery District

(416) 673-8100

ltorvi@marsdd.com

By Nono Hu, Senior Manager, Branding & Messaging, LSN

With 6 days left until RESI Boston 2015, LSN is pleased to announce that this event is the largest RESI since its first kickoff. We have over 550 meetings booked through the RESI Partnering Platform, and have registered nearly 180 early stage investors and more than 400 emerging life science entrepreneurs. As our largest event yet, we have increased your odds of making a compelling connection.

Check out the RESI Program Guide with the schedule of a full day of panels, workshops, and partnering! We hope to see you on September 16 at the Westin Copley Place, Boston.

By Alejandro Zamorano, VP of Business Development, LSN

Life Science Nation attends many partnering conferences, in addition to hosting our own quarterly Redefining Early Stage Investments (RESI) Conference series. After taking the time to study the most successful partnering requests and interviewing investors about what they look for in an introductory note, we have created a template email, which should increase your response rate when soliciting investment:

Frank,

My name is John Doe, CEO, Sample Therapeutics, an early stage therapeutic company based out of New York developing an antibody drug conjugate (ADC) for pancreatic cancer. Our lead asset (OK-101) is in the middle of Phase 1 clinical trials and is open to partnership opportunities.

OK-101 leverages Sample Therapeutics’ proprietary ADC technology to deliver doxorubicin to cancer tissue more efficiently, thereby reducing toxicity and increasing its efficacy. Unlike traditional ADCs, Sample Therapeutics’ platform uses a two-part ADC system in which antigen-specific antibodies are injected into the body first, followed by the small molecule that then binds to the antibodies in the cancer tissue. This system increases the versatility of known ADC technology and avoids the common liver toxicity problems found in traditional systems.

Currently we are at the beginning stages of our fundraising campaign to complete our Phase 2 by Q4 2016. Given your firm’s experience in clinical stage oncology assets, and what I read in your profile our company seems to match your investment interests.

I think we are a good fit for your investment strategy and would like to have an opportunity to connect with you at the RESI Conference.

Let’s break down the email in order to understand its structure.

1^st — Introduce Yourself

Introduce yourself, your title, and the name of your company. Although obvious, you might be surprised by how many people don’t do this.

2^nd — Introduce Your Company

Give a brief overview of your company so that an investor can determine from the first sentence whether you are a fit for their investment mandate. Remember, every investor is unique and therefore not every investor is a fit for your opportunity. Here are five key data points that are likely to affect investor fit:

• Where your company is based
• What sector your company is in (biotech, medtech, diagnostics, healthcare IT, etc)
• The modality you are using
• The indication you are treating or problem you are trying to solve
• Your product’s development phase

3^rd — Key Value Proposition/Elevator Pitch

Use the next part of the email to describe the key value proposition of your technology. This should include a high-level description of the core technology and its major differentiators from currently available products or solutions. This is the core of your messaging and should reveal enough information to pique interest.

4^th — The Stage of Your Fundraising Campaign

You should clearly state where you are in the fundraising process (beginning, middle or end) and what the use of those proceeds will be. This way an investor can gauge if your round is a fit for their capital allocation.

5^th — Reaffirm

You should do your homework on every investor you reach out to and reference a relevant data point to reaffirm the reason you are reaching out.

6^th — The Next Step

Finish the email by laying out when you plan on connecting with them and how the both of you should connect. As this is a conference partnering message, this can be as simple as telling them to accept the meeting request if they would like to meet up.

By sticking to these fundamentals you will make it a lot easier for an investor to identify you as a fit for their investment strategy. This will lead to higher response rates and more productive meetings.

By Lucy Parkinson, Senior Research Manager, LSN

If you’re developing a biotech asset and you’re raising funds in order to complete pre-IND studies, or to embark on your first human clinical trial, this panel will provide an opportunity to hear from investors who focus on companies at this challenging stage of the development process.

Moderated by Steven Gullans, Managing Director, Excel Venture Management, this panel features:

• Isai Piemer, Managing Director, MedImmune Ventures
• Arjun Goyal, Associate, 5AM Ventures
• Jayson Punwami, Principal, Pappas Ventures
• Sam Hall, Principal, Apple Tree Partners

These investors will offer their insights on the challenge of assessing a biotech opportunity prior to attaining human proof of concept data. What factors do they consider indicative of future success? Which fields of technology are the most promising for early-stage biotech investment today? How do you demonstrate the value of a new breakthrough product to a potential investor? We’ll look forward to hearing the panel’s insights on these and other vital questions faced by Preclinical and Phase I biotechs.

By Lucy Parkinson, Senior Research Manager, LSN

Earlier this month, we covered the benefits of using CRM to organize your fundraising campaign. By logging every contact, you can collect useful data points that will map your campaign’s progress. LSN’s advisory arm, Boston Innovation Capital, logs every call made and every email sent during the course of a fundraising campaign in a CRM system. Using data from a current BIC project, we’ll take a look at what it typically takes for a company to get a meeting.

Using the LSN Investor Platform, BIC generated a list of over 250 investors from around the globe as strong potential fits for the company (a US-based medical device developer). The outreach team designed a concise email pitch and a phone message, and performed outreach to all of the investors on the GTL. Thus far, this outreach has generated meetings with 31 investment and strategic firms. But how many outreach attempts did it take to generate a positive response from each investor? As we store all this information in the campaign Salesforce account, it’s easy for us to dive in there and take a look at the road we’ve travelled.

(Note: the y-axis tracks the number of outreach attempts it took before the investor responded with interest in a meeting. In most cases, it took several more exchanges to pin down a suitable meeting time!)

As the chart demonstrates, if you use a targeted outreach method and contact only investors who are a suitable fit for the opportunity, many investors will respond positively to a well-composed email asking for a meeting. In 14 cases, only one message was required in order for the investor to express an interest in a call. However, if we’d stopped at that one message, our client would have missed out on over half of their total meetings. There are more meetings available in the long tail of persistent outreach than there are in the initial email blast.

Making a second, third, fourth, or more attempts to get in touch with an investor will double your outreach success. Persistence will, of course, also help you filter disinterested investors out of the process; investors can hardly follow up on every opportunity that crosses their desk, and receiving a polite decline allows your campaign to continue more efficiently.

We also found it’s important to vary the outreach. It’s good to use calls to follow up on emails; sometimes the investor saw the original mail, but hasn’t had time to take a deep dive on the opportunity yet, and appreciates the reminder. Leaving a voicemail may also nudge the investor into responding to your email. If you’ve not received a response after several attempts, it can pay to do some research on the person you’re reaching out to; if you check on the firm website and on LinkedIn, you may find that their role has changed and they’re no longer the right person to reach out to with a deal. At this point, you may wish to select a different contact to reach out to.

Additionally it’s often useful to speak to an executive assistant at the firm, who may be knowledgeable about whether you’re reaching out to the right contact for your opportunity, and about the best time and means to reach them. (This is especially useful information during the summer, when an investor might be away from their office for an extended period of time!) Asking the right questions could get you referred internally; once passed to the correct person to assess the opportunity, one typically receives a rapid yes/no decision regarding the meeting request.

Persistence pays off when you’re fundraising. Investors are very busy people, and the most important contacts are sometimes the hardest ones to reach. Even after securing an initial meeting and opening a dialogue with an investor, the follow-up process will be lengthy and frustrating. We hope that this data showing the benefits of outreach persistence will keep your spirits up.