LSN Ecosystem Deal Matrix $1.29 Billion and Counting 

15 Oct

By Dennis Ford, Founder & CEO, Life Science Nation (LSN)

DF-News-09142022Across Life Science Nation (LSN)’s interconnected network, from the Investor & Licensing Partner Database and RESI Conference Series to LSN Labs, 90 companies have publicly disclosed raising capital or signing licensing deals sourced directly through LSN.  LSN has been collecting this disclosed data and, after reaching 90 deals, wanted to extrapolate the compelling metrics behind the LSN engine that facilitated the deals, known as the LSN Ecosystem.

Together, they’ve secured $1.29 billion in verified funding. When factoring in the broader global community of 9,000+ startups that have engaged with LSN tools and programs and gone through the RESI turnstiles, the estimated impact reaches $6.4 billion. This isn’t modeled data; these are real companies, real partners, and real outcomes. It’s proof that structured global partnering delivers measurable success.

A Marketplace That Works — and Scales

At first glance, the dataset lists 90 companies and 52 investors. On closer inspection, that ratio reflects how healthy marketplaces behave. Each transaction represents multiple funding relationships, roughly 100 to 150 discrete deals in total, many of which are undisclosed but very much real.

  • For startups, closing $1.29 billion through LSN-facilitated partnerships signals one of the strongest verified conversion rates in early-stage life sciences.
  • For investors, repeat participation by six global funds, including corporate venture, pharma, and family offices, demonstrates a growing cycle of trust and sourcing efficiency within LSN’s ecosystem.

This is not a collection of introductions; it’s a living marketplace where structure, data, and discipline transform intro meetings into ongoing dialogue, building relationships that ultimately lead to transactions.

Where the Money Moves: The Four Domains (4Ds)

SECTOR DISCLOSED FUNDING ($) % SHARE COMMENT
Drugs (Therapeutics) 1,106,490,000 83% Core growth engine for global biotech
Devices (Medtech) 120,820,000 9% Strategic investments and exits rising
Diagnostics & Tools 111,330,000 8% A precision frontier gaining traction
Digital Health Emerging (<1%) Expanding rapidly as AI matures and the software moves adroitly

Therapeutics dominate the dollars, but the deal flow is distributed, indicating a balanced and resilient early-stage market that spans drugs, devices, diagnostics, and digital health alike.

Even Distribution, Uneven Costs

It’s no surprise that therapeutics absorb most of the capital; drug development is costly and front-loaded. A single preclinical or IND-enabling round can match the combined raises of multiple device or diagnostics startups. But when you look at deal volume, not just deal size, the picture changes. The 90 funded companies are evenly distributed across the 4Ds:

SECTOR  COMPANIES FUNDED  SHARE OF TOTAL 
Drugs (Therapeutics)  31 34%
Diagnostics & Tools  26 29%
Devices (Medtech)  23 26%
Digital Health  10 11%

The big money may flow into drugs, but the deals are happening across all four domains. That balance defines a healthy market, diversified, dynamic, and alive.

Average Deal Size Across the 4Ds

SECTOR  AVERAGE RAISE PER COMPANY ($)  INSIGHT 
Drugs (Therapeutics)  $35.7 million Reflects the high capital intensity of preclinical and early clinical development
Devices (Medtech)  $5.3 million Medtech investors focus on de-risked prototypes and regulatory progress
Diagnostics & Tools  $4.3 million Enabling and precision technologies attract steady, mid-range funding
Digital Health  >$3 million Early but fast-growing; deal sizes expected to rise with data maturity

These numbers capture a simple truth: Drug rounds dominate in size, but early-stage innovation thrives across every domain. The LSN ecosystem delivers results across all four, not just where the biggest checks are written.

The Signal: Efficiency Is the New Advantage

As global capital tightens, efficiency wins. With RESI London (Dec 2025) and RESI JPM (Jan 2026) approaching, startups and investors alike are leaning into systems that don’t just connect, they convert. LSN’s rhythm of data, readiness, and disciplined outreach has become the commercialization backbone for early-stage life sciences worldwide.  “At RESI, we don’t chase headlines; we measure outcomes. The companies and investors in this dataset are the proof.”

Join the Momentum. Be Part of the Data.

The next cycle begins now. Don’t miss your chance to access the world’s most effective life science partnering platform.

Registration now open:

  • RESI London 2025 (Dec. 4, 8&9) – [Register]
  • RESI JPM 2026 (Jan.12-14, 19&20)– [Register]
  • RESI Europe 2026 (March 23-25) – [Register]

Will PubMed be Shutdown? 

15 Oct

By Sougato Das, President and COO, LSN

Sougato-Das

Many in the life sciences research community were spooked when PubMed went down temporarily in March after the Trump administration cut $4 billion in “indirect costs” that supported medical research. More recently, an ominous message appeared on PubMed: “Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed…” Many who use PubMed but not other government websites were probably panicked by this, but a quick look at clinicaltrials.gov, NIH Reporter and even NIH’s main site reveals the same message, while different versions of this message appear on the websites of HHS, CMS, etc.

Still, various EU governments have been quietly preparing for a PubMed shutdown by ensuring they will have a PubMed-alternative just in case. Of course, let’s be real: while they may be able to serve the existing content in PubMed, they will not be able to suddenly support the thousands of additional abstracts and articles added each day, along with MeSH tagging, journal selection, XML/JSON feeds, and other critical functions PubMed provides.

While PubMed is critical to nearly every life science researcher, even those with access to Web of Science, Embase, etc., it is especially critical to early-stage life science companies and investors. For basic research, competitive intelligence, due diligence and more, PubMed is indispensable for those without access to paid literature databases. PubMed is also an important source for pipeline database providers that investors and pharma use to find assets and perform CI.

The US government, for decades, has supplied a critical and reliable literature resource for worldwide audiences, both professional and non-professional alike. With the addition of the first and best clinical trial registry in 2000, continued funding for this resource is paramount for global biomedical research.

Host Your JPM Reception, Presentation, Showcase or Partnering at the Marriott Marquis 

15 Oct

By Matt Stanton, VP Sales US West, Central and South America, LSN

JPM is creeping up on you once again, and you still don’t have an event planned. All the good venues are gone and all you’re left with are subprime ones or those with sky-high prices. Why not work with us to plan your best event or partnering table rental at the centrally located Marriott Marquis? RESI JPM will be a two-day event this year: Monday and Tuesday. Life Science Nation has rental space available on Sunday, that will allow you to put your event during what is already a lively ecosystem of early-stage companies and investors. If you already have an event planned, why not do more? If there were ever a time to do more, it’s during JPM.

If you’re a membership organization, you owe it to your members to provide them partnering space at JPM. But getting a partnering table at one of the San Fran hotels will costs at least $1500 per day per table! Contact us to find out how you can get conveniently located partner tables for your members at affordable prices.

Finally, if you’re a product or service provider, sponsoring, exhibiting or attending RESI is, by far, the best opportunity to bang out 50+ meetings with early-stage innovators. RESI is the only partnering conference where companies are more than happy to accept partnering meetings with vendors, as can be seen in our partnering stats. In the RESI partnering system, you won’t find any profiles with the dreaded “no service provider requests”. Additionally, sponsoring or exhibiting at RESI is less than doing so at any of the other main JPM conferences.

See you at JPM!

Secure Your RESI JPM Exhibitor Spot Contact Us to Reserve Event Space

From RESI Boston to Global Growth: Bilix on Winning the Innovator’s Pitch Challenge

15 Oct
Myung Kim
  CaitiCaitlin Dolegowski

Bilix, recognized as a top Innovator’s Pitch Challenge winner at RESI Boston this past September, is making waves in the biotech space with its innovative multi-modality approach to inflammatory and autoimmune diseases. In this interview, Myung Kim, Founder and CEO, shares how participating in RESI Boston helped the company connect with key investors, refine its strategy, and advance its clinical milestones.

Hear firsthand how Bilix is driving progress in complex disease treatment and discover how your company can join the next generation of innovators pitching at RESI London and RESI JPM. Applications are now open.

Apply to Pitch at RESI London Apply to Pitch at RESI JPM

Five Leading Life Science Organisations Collaborate on Inaugural London Bio-Innovation Week 

7 Oct

By Tony Jones, CEO, One Nucleus (Special Guest Contributor)

ELRIG, Life Science Integrates, Life Science Nation, One Nucleus and SLAS will provide delegates with the opportunity for cross-event partnering during London Bio-Innovation week, which runs 1-5 December, 2025

One Nucleus’ Genesis conference partnering app open to delegates attending any of Bio-Innovation Week events

Initiative to provide extended opportunities for networking, to support the life science ecosystem


London, UK, 30 September 2025:ELRIG, Life Science Integrates, Life Science Nation, One Nucleus and The Society for Laboratory Automation and Screening (SLAS) today announced that they will be collaborating during London Bio-Innovation week, to facilitate multi-event networking and partnering opportunities for life science companies.

London Bio-Innovation week, which runs 1-5 December, 2025, will see each of the five organisations delivering events in the UK’s capital city. While each event is being run independently, collectively their co-location in one city provides a unique opportunity to meet with in excess of 1000 of the brightest science and business minds in London that week.

To further support those seeking new collaborations, insights and opportunities, the event organisers will provide the opportunity for cross-event partnering. Delegates attending any one of the Bio-Innovation Week events will be able to access the One Nucleus Genesis app, to connect with delegates attending different conferences.

Tony Jones, CEO, One Nucleus, said: “Collaboration sits at the core of translating world leading bioscience research into new ventures developing innovative products and technologies to improve patient outcomes. With so much activity in London for Bio-Innovation Week, we identified a unique opportunity to support the life science sector, by opening the Genesis conference partnering app to both attendees and non-attendees, providing a platform for partnering across the multiple events.”

London Bio-Innovation Week Events:


About ELRIGhttps://elrig.org/

ELRIG are proud to be a leading European not-for-profit organisation dedicated to uplifting the life science and drug discovery community. Our mission is to foster open access to modern research and innovation. Bringing together our vibrant community of over 12,000 life science professionals from academia and biopharma to connect, collaborate and encourage curiosity.

Contact: Sanj Kumar, CEO sanj.kumar@elrig.org

About Life Science Integrates https://lifescienceintegrates.com/

Formed in 2011 by Christopher Watt and Samuel Thangiah, Life Science Integrates (LSI) brings together Senior Leaders from across the Life Sciences, including industry, academia, government and regulators; providing them with unique opportunities to be part of the conversations that set out the industry’s challenges and identify effective strategies and solutions.

Contact: Samuel Thangiah, Founder and Executive Director samuel.thangiah@lsi-uk.com

About Life Science Nation (RESI) https://www.lifesciencenation.com/

The Redefining Every Stage of Investment (RESI) conference series, provided by Life Science Nation, connects start-ups and investors and strategic licensing partners. RESI maximizes fundraising companies’ efforts to find partners who are a fit for their technology and stage of development. RESI is uniquely cross-border and cross-domain, connecting start-ups with 10 categories of global investors across the silos of drugs, devices, diagnostics and digital health. RESI caters to both the earliest stage start-ups, those seeking grants, seed and angel capital, and the early-stage firms who seek series A and B funding. RESI is a unique and powerful tool for sourcing assets and advancing innovation across early-stage life science and healthcare.

Contact: Greg Manix VP International Business Development g.mannix@lifesciencenation.com

About One Nucleus https://onenucleus.com/

One Nucleus is a not-for-profit Life Sciences & Healthcare membership organisation headquartered in Cambridge. We support institutions, companies and individuals in the Life Sciences sector providing local, UK-wide and international connectivity.

Contact: Tony Jones, CEO tony@onenucleus.com

About SLAS https://www.slas.org/

The Society for Laboratory Automation and Screening is the global leader in bringing life sciences researchers and laboratory technology providers together under one roof for knowledge sharing and collaboration aimed at transforming research. Annually, SLAS holds its must-attend International Conference & Exhibition in the U.S. and its Europe Conference and Exhibition, with opportunities for start-ups to gain exposure to thousands of potential customers, as well as award opportunities for scientific content by way of poster presentations and the annual Innovation Award. Regular networking events around the world enable regional communities to come together to strengthen research collaboration.

Contact: Vicki Loise, CEO vloise@slas.org or SLAS Europe Ambassador, Manuela Beil-Peter, mbeilpeter@slas.org

Media Contact Information :

Media contact

Lorna Cuddon
Zyme Communications
Tel: +44(0)7811 996 942
Email: lorna.cuddon@zymecommunications.com

Tony Jones, One Nucleus
email: tony@onenucleus.com

Register for RESI London Register for RESI & Genesis Combi Ticket

 

How 100% Pharma Tariffs Could Ripple Through Early-Stage Biotech Investment 

7 Oct

By Sougato Das, President and COO, LSN

Sougato-Das

We have all heard about the recent 100% pharma tariff announcement, applicable mainly to manufacturers or marketed drugs unless they are in the process of building manufacturing facilities in the US. We know that early stage biotechs are generally not counting on investment to take them through manufacturing, for which they will seek a pharma partner. Nevertheless, these tariffs may still have an effect on early-stage biotech investments. Investment in early-stage (seed, Series A/B) biotech is likely to face increased headwinds under a 100 % pharmaceutical tariff regime. The tariff risk exacerbates existing structural challenges in biotech investing.

Overall Expected Effect (Short to Medium Term) 

  • Slower fundraising pace 
    The number of deals may decline, particularly in the earlier stages. Biotech investors will likely become more selective, preferring de-risked assets, strong data, or compelling platforms with clear strategies to mitigate tariff exposure.
  • Higher effective cost of capital 
    Investors will demand more upside or stricter protections (e.g. liquidation preferences, anti-dilution) to compensate for the added risk.
  • Greater emphasis on capital efficiency / leaner burn models 
    Startups may need to conserve cash more, focus earlier on key inflection points, outsource less, and plan fallback strategies for supply chain risk.
  • Longer timelines / delayed exits 
    Because of the risk, uncertainty, and possible delays, the time to IPO, acquisition, or commercialization may stretch, further compressing IRR for investors.
  • Capital flow shift toward infrastructure and enabling technologies 
    Some portion of venture capital may redirect toward bioprocessing, domestic manufacturing, synthetic biology for local API production, supply-chain tools — companies that can help others evade tariff impact.
  • Public market investment in pharma may slow, leading to less IPOs 
    The tariffs could serve to further erode the attractiveness of the biopharma sector for public market investors, reducing the room for IPOs, and pressuring investment taking place more upstream.

In summary, while the recent 100% pharma tariffs certainly don’t have a direct effect on early-stage biotech investing, their dampening effects will nonetheless be felt.

Hot Investor Mandate: North America Based Family Office Seeking Early and Late Stage Opportunities in Life Sciences with Technology Angle 

7 Oct

The firm is a family office spin-off established in 2023 with offices in New York and Toronto, Canada. The firm invests globally through two complementary arms. The early-stage arm focuses on Pre-Seed and Seed opportunities in North America, typically writing first checks between USD $500k–2.5M into deeptech companies. The later-stage arm is dedicated exclusively to life sciences investments, with flexibility on check sizes and a global focus. While the firm does not typically lead rounds, it participates actively on a case-by-case basis. 

The early-stage strategy emphasizes deeptech companies—such as biotech, AI, space-tech, and medtech—while generally avoiding pure life sciences unless there is a strong technology angle, such as medical devices. The later-stage strategy targets Phase I–III ready drug assets. The firm is disease-agnostic, including orphan indications, but prefers companies addressing at least 5% of the population. Across both strategies, the firm favors companies pursuing FDA approval in the U.S. 

The firm does not have strict company or management team requirements, but appreciates teams with academic backgrounds or ties to universities. 

If you are interested in more information about this investor and other investors tracked by LSN, please email salescore@lifesciencenation.com